-(2-amino-3-cyclohexyl-1-hydroxypropyl)phosphonic acid, dimethyl ester, hydrochloride

Base Information

• Chemical Name: -(2-amino-3-cyclohexyl-1-hydroxypropyl)phosphonic acid, dimethyl ester, hydrochloride
• CAS No.: 131372-76-4
• Molecular Formula: C₁₁H₂₄NO₄P*ClH
• Molecular Weight: 301.751

Synonyms:-(2-amino-3-cyclohexyl-1-hydroxypropyl)phosphonic acid, dimethyl ester, hydrochloride

Chemical Property of -(2-amino-3-cyclohexyl-1-hydroxypropyl)phosphonic acid, dimethyl ester, hydrochloride

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Technology Process of -(2-amino-3-cyclohexyl-1-hydroxypropyl)phosphonic acid, dimethyl ester, hydrochloride

There total 2 articles about -(2-amino-3-cyclohexyl-1-hydroxypropyl)phosphonic acid, dimethyl ester, hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.6%

<1-(cyclohexylmethyl)-2-(dimethoxyphosphinyl)-2-hydroxyethyl>carbamic acid, 1,1-dimethylethyl ester → -(2-amino-3-cyclohexyl-1-hydroxypropyl)phosphonic acid, dimethyl ester, hydrochloride (131372-76-4)

Guidance literature:

With hydrogenchloride; In ethyl acetate; at 0 ℃; for 6.5h;

DOI:10.1021/jm00022a022

Reference yield:

-<1-(cyclohexylmethyl)-2-(dimethoxyphosphinyl)-2-hydroxyethyl>carbamic acid, 1,1-dimethylethyl ester (125399-34-0) → -(2-amino-3-cyclohexyl-1-hydroxypropyl)phosphonic acid, dimethyl ester, hydrochloride (131372-76-4)

Guidance literature:

With hydrogenchloride; In ethyl acetate; at 0 ℃; for 2h;

DOI:10.1016/S0040-4039(00)97903-6

Reference yield: 65.3%

-(2-amino-3-cyclohexyl-1-hydroxypropyl)phosphonic acid, dimethyl ester, hydrochloride (131372-76-4) + N(α)-t-butoxycarbonyl-N(?)-benzyloxymethyl-L-histidine (83468-83-1) → (1S,2S)-N-<1-(cyclohexylmethyl)-2-(dimethoxyphosphinyl)-2-hydroxyethyl>-N2-<(1,1-dimethylethoxy)carbonyl>-3-<(phenylmethoxy)methyl>-L-histidinamide

Guidance literature:

With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In N,N-dimethyl-formamide; at 25 ℃; for 16h;

DOI:10.1021/jm00022a022

upstream raw materials:

-<1-(cyclohexylmethyl)-2-(dimethoxyphosphinyl)-2-hydroxyethyl>carbamic acid, 1,1-dimethylethyl ester

Downstream raw materials:

(1S,2S)-N-<1-(cyclohexylmethyl)-2-(dimethoxyphosphinyl)-2-hydroxyethyl>-N²--L-phenylalanyl>-L-leucinamide

{(1S,2S)-2-[(S)-3-(3-Benzyloxymethyl-3H-imidazol-4-yl)-2-tert-butoxycarbonylamino-propionylamino]-3-cyclohexyl-1-hydroxy-propyl}-phosphonic acid dimethyl ester

((1S,2S)-2-{(S)-2-tert-Butoxycarbonylamino-3-[1-(2,4-dinitro-phenyl)-1H-imidazol-4-yl]-propionylamino}-3-cyclohexyl-1-hydroxy-propyl)-phosphonic acid dimethyl ester

(1S,2S)-N-<1-(cyclohexylmethyl)-2-(dimethoxyphosphinyl)-2-hydroxyethyl>-N²-<(1,1-dimethylethoxy)carbonyl>-L-leucinamide

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