Technology Process of {1-[2-(4-phenyl-butyl)-benzofuran-4-yl]-pyrrolidin-3-yl}-carbamic acid tert-butyl ester
There total 9 articles about {1-[2-(4-phenyl-butyl)-benzofuran-4-yl]-pyrrolidin-3-yl}-carbamic acid tert-butyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl;
In
toluene;
Heating;
DOI:10.1016/j.bmcl.2004.07.055
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 85 percent / n-BuLi / tetrahydrofuran / 0 - 25 °C
2: 99 percent / H2 / Pd/C / ethyl acetate
3: 96 percent / LiAlH4 / tetrahydrofuran / 20 °C
4: 90 percent / (COCl)2; DMSO; Et3N / CH2Cl2
5: MCPBA / CHCl3
6: HCl / methanol
7: pyridine / 0 - 25 °C
8: 90 percent / Pd(OAc)2; BINAP; Cs2CO3 / toluene / Heating
With
pyridine; hydrogenchloride; palladium diacetate; lithium aluminium tetrahydride; n-butyllithium; oxalyl dichloride; hydrogen; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; dimethyl sulfoxide; triethylamine; 3-chloro-benzenecarboperoxoic acid;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; dichloromethane; chloroform; ethyl acetate; toluene;
1: Wittig olefination / 4: Swern oxidation / 5: Baeyer-Villiger oxidation;
DOI:10.1016/j.bmcl.2004.07.055
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 85 percent / n-BuLi / tetrahydrofuran / 0 - 25 °C
2: 99 percent / H2 / Pd/C / ethyl acetate
3: 96 percent / LiAlH4 / tetrahydrofuran / 20 °C
4: 90 percent / (COCl)2; DMSO; Et3N / CH2Cl2
5: MCPBA / CHCl3
6: HCl / methanol
7: pyridine / 0 - 25 °C
8: 90 percent / Pd(OAc)2; BINAP; Cs2CO3 / toluene / Heating
With
pyridine; hydrogenchloride; palladium diacetate; lithium aluminium tetrahydride; n-butyllithium; oxalyl dichloride; hydrogen; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; dimethyl sulfoxide; triethylamine; 3-chloro-benzenecarboperoxoic acid;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; dichloromethane; chloroform; ethyl acetate; toluene;
1: Wittig olefination / 4: Swern oxidation / 5: Baeyer-Villiger oxidation;
DOI:10.1016/j.bmcl.2004.07.055