C₃₀H₄₄O₂Si₂

Base Information

• Chemical Name: C₃₀H₄₄O₂Si₂
• CAS No.: 172516-14-2
• Molecular Formula: C₃₀H₄₄O₂Si₂
• Molecular Weight: 492.849
• Mol file: 172516-14-2.mol

Synonyms:C₃₀H₄₄O₂Si₂

Chemical Property of C₃₀H₄₄O₂Si₂

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₀H₄₄O₂Si₂

There total 7 articles about C₃₀H₄₄O₂Si₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

t-butyldimethylsiyl triflate (69739-34-0) + (4R,6S)-6-(tert-Butyl-diphenyl-silanyloxy)-oct-7-en-1-yn-4-ol (167892-85-5) → C30H44O2Si2 (172516-14-2)

Guidance literature:

With 2,6-dimethylpyridine; In dichloromethane; at 0 ℃; for 0.5h;

DOI:10.1016/0040-4039(95)01902-T

Reference yield:

tert-butyl 3-hydroxypent-4-enoate (122763-67-1) → C30H44O2Si2 (172516-14-2)

Guidance literature:

Multi-step reaction with 6 steps

1: 45 percent / lipase PS Amano / pentane / 45 h / 30 °C

2: K₂CO₃ / methanol / 1.5 h / Ambient temperature

3: imidazole / dimethylformamide / 5 h / 55 °C

4: 91 percent / DIBAL-H / toluene / 0.25 h / -78 °C

5: 61 percent / Zn / tetrahydrofuran / 0.75 h / -30 °C

6: 99 percent / 2,6-lutidine / CH₂Cl₂ / 0.5 h / 0 °C

With 1H-imidazole; 2,6-dimethylpyridine; Lipase PS Amano; diisobutylaluminium hydride; potassium carbonate; zinc; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene; pentane;

DOI:10.1016/0040-4039(95)01902-T

Reference yield:

tert-butylchlorodiphenylsilane (58479-61-1) → C30H44O2Si2 (172516-14-2)

Guidance literature:

Multi-step reaction with 4 steps

1: imidazole / dimethylformamide / 5 h / 55 °C

2: 91 percent / DIBAL-H / toluene / 0.25 h / -78 °C

3: 61 percent / Zn / tetrahydrofuran / 0.75 h / -30 °C

4: 99 percent / 2,6-lutidine / CH₂Cl₂ / 0.5 h / 0 °C

With 1H-imidazole; 2,6-dimethylpyridine; diisobutylaluminium hydride; zinc; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; toluene;

DOI:10.1016/0040-4039(95)01902-T

upstream raw materials:

t-butyldimethylsiyl triflate

(4R,6S)-6-(tert-Butyl-diphenyl-silanyloxy)-oct-7-en-1-yn-4-ol

tert-butyl 3-hydroxypent-4-enoate

tert-butylchlorodiphenylsilane

Downstream raw materials:

(5R,7S)-5-(tert-Butyl-dimethyl-silanyloxy)-7-(tert-butyl-diphenyl-silanyloxy)-non-8-en-2-yn-1-ol

(Z)-(5S,7S)-5-(tert-Butyl-dimethyl-silanyloxy)-7-(tert-butyl-diphenyl-silanyloxy)-3-iodo-nona-2,8-dien-1-ol