1-{[(1S)-1-methyl-3-oxocyclohexaneyl]methyl}-1H-benzimidazole-6-carbonitrile

Base Information

Chemical Name:1-{[(1S)-1-methyl-3-oxocyclohexaneyl]methyl}-1H-benzimidazole-6-carbonitrile
CAS No.:1416324-31-6
Molecular Formula:C₁₆H₁₇N₃O
Molecular Weight:267.33
Hs Code.:

Synonyms:1-{[(1S)-1-methyl-3-oxocyclohexaneyl]methyl}-1H-benzimidazole-6-carbonitrile

Suppliers and Price of 1-{[(1S)-1-methyl-3-oxocyclohexaneyl]methyl}-1H-benzimidazole-6-carbonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 2 raw suppliers

Chemical Property of 1-{[(1S)-1-methyl-3-oxocyclohexaneyl]methyl}-1H-benzimidazole-6-carbonitrile

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 1-{[(1S)-1-methyl-3-oxocyclohexaneyl]methyl}-1H-benzimidazole-6-carbonitrile

There total 8 articles about 1-{[(1S)-1-methyl-3-oxocyclohexaneyl]methyl}-1H-benzimidazole-6-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1416324-30-5
1-{[(2R,3R,7S)-7-methyl-2,3-diphenyl-1,4-dioxaspiro[4,5]dec-7-yl]methyl}-1H-benzimidazole-6-carbonitrile

: 1416324-31-6
1-{[(1S)-1-methyl-3-oxocyclohexaneyl]methyl}-1H-benzimidazole-6-carbonitrile

Guidance literature:: 1-{[(2R,3R,7S)-7-methyl-2,3-diphenyl-1,4-dioxaspiro[4,5]dec-7-yl]methyl}-1H-benzimidazole-6-carbonitrile; With formic acid; at 70 ℃; for 18h;

With sodium hydrogencarbonate;

Reference yield:

: 1193-18-6
3-methylcyclohexen-2-one

: 1416324-31-6
1-{[(1S)-1-methyl-3-oxocyclohexaneyl]methyl}-1H-benzimidazole-6-carbonitrile

Guidance literature:: Multi-step reaction with 8 steps

1: pyridinium p-toluenesulfonate / benzene / 72 h / 115 °C

2: zinc; copper; iodine / diethyl ether / 1.5 h / Inert atmosphere; Reflux

3: hydrogen bromide / water; methanol / 24 h / 20 °C

4: 1-methyl-pyrrolidin-2-one / 120 h / 120 - 130 °C

5: hydrazine / methanol / 2 h / Reflux

6: potassium carbonate / acetonitrile / 20 - 40 °C

7: formic acid / ethyl acetate; methanol / 3.5 h / 64 °C

8: formic acid / 18 h / 70 °C

With formic acid; hydrogen bromide; iodine; pyridinium p-toluenesulfonate; copper; potassium carbonate; hydrazine; zinc; In 1-methyl-pyrrolidin-2-one; methanol; diethyl ether; water; ethyl acetate; acetonitrile; benzene;

Reference yield:

: 1416324-27-0
(2R,3R,7S)-7-(bromomethyl)-7-methyl-2,3-diphenyl-1,4-dioxaspiro[4.5]decane

: 1416324-31-6
1-{[(1S)-1-methyl-3-oxocyclohexaneyl]methyl}-1H-benzimidazole-6-carbonitrile

Guidance literature:: Multi-step reaction with 5 steps

1: 1-methyl-pyrrolidin-2-one / 120 h / 120 - 130 °C

2: hydrazine / methanol / 2 h / Reflux

3: potassium carbonate / acetonitrile / 20 - 40 °C

4: formic acid / ethyl acetate; methanol / 3.5 h / 64 °C

5: formic acid / 18 h / 70 °C

With formic acid; potassium carbonate; hydrazine; In 1-methyl-pyrrolidin-2-one; methanol; ethyl acetate; acetonitrile;