1-(((1S,3S)-3-(((4,6-dimethoxypyridin-3-yl)amino)methyl)-3-hydroxy-1-methylcyclohexaneyl)methyl)-1H-benzo[d]imidazole-6-carbonitrile

Base Information

• Chemical Name: 1-(((1S,3S)-3-(((4,6-dimethoxypyridin-3-yl)amino)methyl)-3-hydroxy-1-methylcyclohexaneyl)methyl)-1H-benzo[d]imidazole-6-carbonitrile
• CAS No.: 1419610-69-7
• Molecular Formula: C₂₄H₂₉N₅O₃
• Molecular Weight: 435.526
• Mol file: 1419610-69-7.mol

Synonyms:1-(((1S,3S)-3-(((4,6-dimethoxypyridin-3-yl)amino)methyl)-3-hydroxy-1-methylcyclohexaneyl)methyl)-1H-benzo[d]imidazole-6-carbonitrile

Chemical Property of 1-(((1S,3S)-3-(((4,6-dimethoxypyridin-3-yl)amino)methyl)-3-hydroxy-1-methylcyclohexaneyl)methyl)-1H-benzo[d]imidazole-6-carbonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(((1S,3S)-3-(((4,6-dimethoxypyridin-3-yl)amino)methyl)-3-hydroxy-1-methylcyclohexaneyl)methyl)-1H-benzo[d]imidazole-6-carbonitrile

There total 11 articles about 1-(((1S,3S)-3-(((4,6-dimethoxypyridin-3-yl)amino)methyl)-3-hydroxy-1-methylcyclohexaneyl)methyl)-1H-benzo[d]imidazole-6-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.6%

4,6-bis(methyloxy)-3-pyridinamine (89943-34-0) + 1-{[(3S,5S)-5-methyl-1-oxaspiro[2.5]oct-5-yl]methyl}-1H-benzimidazole-6-carbonitrile (1416324-68-9) → 1-(((1S,3S)-3-(((4,6-dimethoxypyridin-3-yl)amino)methyl)-3-hydroxy-1-methylcyclohexaneyl)methyl)-1H-benzo[d]imidazole-6-carbonitrile (1419610-69-7)

Guidance literature:

In isopropyl alcohol; Reflux;

Reference yield:

(2R,3R,7S)-7-(bromomethyl)-7-methyl-2,3-diphenyl-1,4-dioxaspiro[4.5]decane (1416324-27-0) → 1-(((1S,3S)-3-(((4,6-dimethoxypyridin-3-yl)amino)methyl)-3-hydroxy-1-methylcyclohexaneyl)methyl)-1H-benzo[d]imidazole-6-carbonitrile (1419610-69-7)

Guidance literature:

Multi-step reaction with 6 steps

1.1: potassium phtalimide / 1-methyl-pyrrolidin-2-one / 120 h / 120 - 130 °C

1.2: 2 h / Reflux

2.1: potassium carbonate / acetonitrile / 2 h / 40 °C

3.1: formic acid; iron / methanol; ethyl acetate / 3.5 h / 64 °C

4.1: formic acid / 18 h / 70 °C

5.1: potassium tert-butylate / dimethyl sulfoxide / 1 h / 20 - 35 °C

6.1: isopropyl alcohol / Reflux

With formic acid; potassium tert-butylate; iron; potassium carbonate; potassium phtalimide; In 1-methyl-pyrrolidin-2-one; methanol; dimethyl sulfoxide; ethyl acetate; isopropyl alcohol; acetonitrile;

Reference yield:

{[(2R,3R,7S)-7-methyl-2,3-diphenyl-1,4-dioxaspiro[4.5]dec-7-yl]methyl}amine (1416324-28-1) → 1-(((1S,3S)-3-(((4,6-dimethoxypyridin-3-yl)amino)methyl)-3-hydroxy-1-methylcyclohexaneyl)methyl)-1H-benzo[d]imidazole-6-carbonitrile (1419610-69-7)

Guidance literature:

Multi-step reaction with 5 steps

1: potassium carbonate / acetonitrile / 2 h / 40 °C

2: formic acid; iron / methanol; ethyl acetate / 3.5 h / 64 °C

3: formic acid / 18 h / 70 °C

4: potassium tert-butylate / dimethyl sulfoxide / 1 h / 20 - 35 °C

5: isopropyl alcohol / Reflux

With formic acid; potassium tert-butylate; iron; potassium carbonate; In methanol; dimethyl sulfoxide; ethyl acetate; isopropyl alcohol; acetonitrile;

upstream raw materials:

(2R,3R,7S)-7-(bromomethyl)-7-methyl-2,3-diphenyl-1,4-dioxaspiro[4.5]decane

{[(2R,3R,7S)-7-methyl-2,3-diphenyl-1,4-dioxaspiro[4.5]dec-7-yl]methyl}amine

3-({[(2R,3R,7S)-7-methyl-2,3-diphenyl-1,4-dioxaspiro[4,5]dec-7-yl]methyl}amino)-4-nitrobenzonitrile

1-{[(2R,3R,7S)-7-methyl-2,3-diphenyl-1,4-dioxaspiro[4,5]dec-7-yl]methyl}-1H-benzimidazole-6-carbonitrile