Boc-Ser-Glu-Leu-Lys(Z)-Ser-Phe-Pro-OMe

Base Information

• Chemical Name: Boc-Ser-Glu-Leu-Lys(Z)-Ser-Phe-Pro-OMe
• CAS No.: 131697-02-4
• Molecular Formula: C₅₁H₇₄N₈O₁₆
• Molecular Weight: 1055.19
• Mol file: 131697-02-4.mol

Synonyms:Boc-Ser-Glu-Leu-Lys(Z)-Ser-Phe-Pro-OMe

Chemical Property of Boc-Ser-Glu-Leu-Lys(Z)-Ser-Phe-Pro-OMe

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Boc-Ser-Glu-Leu-Lys(Z)-Ser-Phe-Pro-OMe

There total 12 articles about Boc-Ser-Glu-Leu-Lys(Z)-Ser-Phe-Pro-OMe which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.5%

Boc-Ser-Glu-Leu-N3 + H-Lys(Z)-Ser-Phe-Pro-OMe*TFA → Boc-Ser-Glu-Leu-Lys(Z)-Ser-Phe-Pro-OMe (131697-02-4)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at 4 ℃;

DOI:10.1248/cpb.38.2369

Reference yield:

Boc-Glu(OBzl)-ONp (7536-59-6) → Boc-Ser-Glu-Leu-Lys(Z)-Ser-Phe-Pro-OMe (131697-02-4)

Guidance literature:

Multi-step reaction with 7 steps

1: 73.8 percent / dimethylformamide / Ambient temperature

2: 6.4 N HCl / dioxane

3: 77.2 percent / NEt₃ / dimethylformamide / 4 °C

4: 71.2 percent / H₂ / Pd / methanol

5: 67.9 percent / 90percent hydrazine hydrate / ethanol / Ambient temperature

6: isopentyl nitrite

7: 36.5 percent / NEt₃ / dimethylformamide / 4 °C

With hydrogenchloride; hydrogen; hydrazine hydrate; triethylamine; isopentyl nitrite; palladium; In 1,4-dioxane; methanol; ethanol; N,N-dimethyl-formamide;

DOI:10.1248/cpb.38.2369

Reference yield:

benzyl (S)-4-((tert-butoxycarbonyl)amino)-5-(((S)-1-methoxy-4-methyl-1-oxopentan-2-yl)amino)-5-oxopentanoate (122668-41-1,62324-33-8) → Boc-Ser-Glu-Leu-Lys(Z)-Ser-Phe-Pro-OMe (131697-02-4)

Guidance literature:

Multi-step reaction with 6 steps

1: 6.4 N HCl / dioxane

2: 77.2 percent / NEt₃ / dimethylformamide / 4 °C

3: 71.2 percent / H₂ / Pd / methanol

4: 67.9 percent / 90percent hydrazine hydrate / ethanol / Ambient temperature

5: isopentyl nitrite

6: 36.5 percent / NEt₃ / dimethylformamide / 4 °C

With hydrogenchloride; hydrogen; hydrazine hydrate; triethylamine; isopentyl nitrite; palladium; In 1,4-dioxane; methanol; ethanol; N,N-dimethyl-formamide;

DOI:10.1248/cpb.38.2369

upstream raw materials:

Boc-Glu(OBzl)-ONp

methyl ((benzyloxy)carbonyl)-L-phenylalanyl-L-prolinate

benzyl (S)-4-((tert-butoxycarbonyl)amino)-5-(((S)-1-methoxy-4-methyl-1-oxopentan-2-yl)amino)-5-oxopentanoate

Boc-Ser-Glu-Leu-OMe