N-(3-(3,4-dichlorophenyl)propyl)-6-ethyl-3-methoxy-1-methyl-2-oxo-1,2-dihydropyridine-4-carboxamide

Base Information

Chemical Name:N-(3-(3,4-dichlorophenyl)propyl)-6-ethyl-3-methoxy-1-methyl-2-oxo-1,2-dihydropyridine-4-carboxamide
CAS No.:1429204-62-5
Molecular Formula:C₁₉H₂₂Cl₂N₂O₃
Molecular Weight:397.301
Hs Code.:

Synonyms:N-(3-(3,4-dichlorophenyl)propyl)-6-ethyl-3-methoxy-1-methyl-2-oxo-1,2-dihydropyridine-4-carboxamide

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Chemical Property of N-(3-(3,4-dichlorophenyl)propyl)-6-ethyl-3-methoxy-1-methyl-2-oxo-1,2-dihydropyridine-4-carboxamide

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Technology Process of N-(3-(3,4-dichlorophenyl)propyl)-6-ethyl-3-methoxy-1-methyl-2-oxo-1,2-dihydropyridine-4-carboxamide

There total 6 articles about N-(3-(3,4-dichlorophenyl)propyl)-6-ethyl-3-methoxy-1-methyl-2-oxo-1,2-dihydropyridine-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 1429204-61-4
6-ethyl-3-methoxy-1-methyl-2-oxo-1,2-dihydropyridine-4-carboxylic acid

: 76706-60-0
3-(3,4-dichlorophenyl)propan-1-amine

: 1429204-62-5
N-(3-(3,4-dichlorophenyl)propyl)-6-ethyl-3-methoxy-1-methyl-2-oxo-1,2-dihydropyridine-4-carboxamide

Guidance literature:: With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 1429204-40-9
ethyl 6-bromo-3-methoxy-1-methyl-2-oxo-1,2-dihydropyridine-4-carboxylate

: 1429204-62-5
N-(3-(3,4-dichlorophenyl)propyl)-6-ethyl-3-methoxy-1-methyl-2-oxo-1,2-dihydropyridine-4-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: bis-triphenylphosphine-palladium(II) chloride / toluene / 80 °C / Microwave irradiation

2: hydrogen; palladium 10% on activated carbon / methanol / 2 h / 20 °C

3: lithium hydroxide / tetrahydrofuran; methanol / 55 °C

4: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / dichloromethane; N,N-dimethyl-formamide / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; palladium 10% on activated carbon; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1429204-60-3
ethyl 6-ethyl-3-methoxy-1-methyl-2-oxo-1,2-dihydropyridine-4-carboxylate

: 1429204-62-5
N-(3-(3,4-dichlorophenyl)propyl)-6-ethyl-3-methoxy-1-methyl-2-oxo-1,2-dihydropyridine-4-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: lithium hydroxide / tetrahydrofuran; methanol / 55 °C

2: N-ethyl-N,N-diisopropylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / dichloromethane; N,N-dimethyl-formamide / 20 °C

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;