2-[({3-methyl-5-[(E)-2-(4-methylphenyl)-1-ethenyl]-4-isoxazolyl}amino)carbonyl]benzoic acid

Base Information

• Chemical Name: 2-[({3-methyl-5-[(E)-2-(4-methylphenyl)-1-ethenyl]-4-isoxazolyl}amino)carbonyl]benzoic acid
• CAS No.: 957466-38-5
• Molecular Formula: C₂₁H₁₈N₂O₄
• Molecular Weight: 362.385
• Mol file: 957466-38-5.mol

Synonyms:2-[({3-methyl-5-[(E)-2-(4-methylphenyl)-1-ethenyl]-4-isoxazolyl}amino)carbonyl]benzoic acid

Chemical Property of 2-[({3-methyl-5-[(E)-2-(4-methylphenyl)-1-ethenyl]-4-isoxazolyl}amino)carbonyl]benzoic acid

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

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Technology Process of 2-[({3-methyl-5-[(E)-2-(4-methylphenyl)-1-ethenyl]-4-isoxazolyl}amino)carbonyl]benzoic acid

There total 1 articles about 2-[({3-methyl-5-[(E)-2-(4-methylphenyl)-1-ethenyl]-4-isoxazolyl}amino)carbonyl]benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

4-amino-3-methyl-5-[(E)-2-(4-methylphenyl)-1-ethenyl]isoxazole (881398-62-5) + phthalic anhydride (85-44-9) → 2-[({3-methyl-5-[(E)-2-(4-methylphenyl)-1-ethenyl]-4-isoxazolyl}amino)carbonyl]benzoic acid (957466-38-5)

Guidance literature:

at 20 ℃; for 4h; solid state reaction;

DOI:10.1002/jhet.5570440529

Reference yield: 94.0%

4,5-Dichloro-1,2-phenylenediamine (5348-42-5) + 2-[({3-methyl-5-[(E)-2-(4-methylphenyl)-1-ethenyl]-4-isoxazolyl}amino)carbonyl]benzoic acid (957466-38-5) → N1-{3-methyl-5[(E)-2-(4-methylphenyl)-1-ethenyl]-4-isoxazolyl}-2-(5,6-dichloro-1H-benzo[d]imidazol-2-yl)benzamide

Guidance literature:

With boron trifluoride diethyl etherate; In dichloromethane; at 20 ℃; for 8h;

DOI:10.1002/jhet.5570440529

Reference yield: 87.0%

2-[({3-methyl-5-[(E)-2-(4-methylphenyl)-1-ethenyl]-4-isoxazolyl}amino)carbonyl]benzoic acid (957466-38-5) + 1,2-diamino-benzene (95-54-5) → N1-{3-methyl-5[(E)-2-(4-methylphenyl)-1-ethenyl]-4-isoxazolyl}-2-(1H-benzo[d]imidazol-2-yl)benzamide

Guidance literature:

With boron trifluoride diethyl etherate; In dichloromethane; at 20 ℃; for 8h;

DOI:10.1002/jhet.5570440529

upstream raw materials:

4-amino-3-methyl-5-[(E)-2-(4-methylphenyl)-1-ethenyl]isoxazole

phthalic anhydride