2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-N-[1-(piperazine-1-carbonyl)-cyclopentyl]-benzenesulfonamide

Base Information

Chemical Name:2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-N-[1-(piperazine-1-carbonyl)-cyclopentyl]-benzenesulfonamide
CAS No.:635698-18-9
Molecular Formula:C₂₈H₃₂Cl₂N₄O₄S
Molecular Weight:591.558
Hs Code.:

Synonyms:2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-N-[1-(piperazine-1-carbonyl)-cyclopentyl]-benzenesulfonamide

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Chemical Property of 2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-N-[1-(piperazine-1-carbonyl)-cyclopentyl]-benzenesulfonamide

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Technology Process of 2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-N-[1-(piperazine-1-carbonyl)-cyclopentyl]-benzenesulfonamide

There total 5 articles about 2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-N-[1-(piperazine-1-carbonyl)-cyclopentyl]-benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 635698-15-6
4-{1-[2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-benzenesulfonylamino]-cyclopentanecarbonyl}-piperazine-1-carboxylic acid tert-butyl ester

: 635698-18-9
2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-N-[1-(piperazine-1-carbonyl)-cyclopentyl]-benzenesulfonamide

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; methanol; at 20 ℃; for 1h;

Reference yield:

: 635698-09-8
1-[2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-benzenesulfonylamino]-cyclopentanecarboxylic acid

: 635698-18-9
2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-N-[1-(piperazine-1-carbonyl)-cyclopentyl]-benzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide; 1-hydroxybenzotriazole / CH₂Cl₂ / 1 h / cooling

1.2: diisopropylethylamine / CH₂Cl₂ / 20 °C

2.1: HCl / ethyl acetate; dioxane / 20 °C

With hydrogenchloride; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In 1,4-dioxane; dichloromethane; ethyl acetate;
DOI:10.1021/jm061143k

Reference yield:

: 188440-21-3
3-bromomethyl-2,4-dichlorobenzenesulphonyl chloride

: 635698-18-9
2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-N-[1-(piperazine-1-carbonyl)-cyclopentyl]-benzenesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: K₂CO₃ / dimethylformamide / 18 h / 20 °C

1.2: KI; K₂CO₃ / acetone / 7 h / Heating

2.1: LiOH; H₂O / tetrahydrofuran; methanol / 4 h / Heating

3.1: N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide; 1-hydroxybenzotriazole / CH₂Cl₂ / 1 h / cooling

3.2: diisopropylethylamine / CH₂Cl₂ / 20 °C

4.1: HCl / ethyl acetate; dioxane / 20 °C

With hydrogenchloride; lithium hydroxide; water; potassium carbonate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm061143k