1-[2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-benzenesulfonylamino]-cyclopentanecarboxylic acid methyl ester

Base Information

• Chemical Name: 1-[2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-benzenesulfonylamino]-cyclopentanecarboxylic acid methyl ester
• CAS No.: 635697-88-0
• Molecular Formula: C₂₅H₂₆Cl₂N₂O₅S
• Molecular Weight: 537.464

Synonyms:1-[2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-benzenesulfonylamino]-cyclopentanecarboxylic acid methyl ester

Chemical Property of 1-[2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-benzenesulfonylamino]-cyclopentanecarboxylic acid methyl ester

Chemical Property:

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Technology Process of 1-[2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-benzenesulfonylamino]-cyclopentanecarboxylic acid methyl ester

There total 3 articles about 1-[2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-benzenesulfonylamino]-cyclopentanecarboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-bromomethyl-2,4-dichlorobenzenesulphonyl chloride (188440-21-3) + cycloleucine methyl ester (78388-61-1) + 8-hydroxy-2,4-dimethylquinoline (115310-98-0) → 1-[2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-benzenesulfonylamino]-cyclopentanecarboxylic acid methyl ester (635697-88-0)

Guidance literature:

3-bromomethyl-2,4-dichlorobenzenesulphonyl chloride; cycloleucine methyl ester; With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 18h;

8-hydroxy-2,4-dimethylquinoline; With potassium carbonate; potassium iodide; In acetone; for 7h; Heating;

DOI:10.1021/jm061143k

Reference yield:

2,4-Dichloro-3-methylbenzenesulfonyl chloride (69145-58-0) → 1-[2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-benzenesulfonylamino]-cyclopentanecarboxylic acid methyl ester (635697-88-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: N-bromosuccinimide; AIBN / CCl₄

2.1: K₂CO₃ / dimethylformamide / 18 h / 20 °C

2.2: KI; K₂CO₃ / acetone / 7 h / Heating

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); potassium carbonate; In tetrachloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jm061143k

Reference yield:

→ 1-[2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-benzenesulfonylamino]-cyclopentanecarboxylic acid methyl ester (635697-88-0)

Guidance literature:

upstream raw materials:

3-bromomethyl-2,4-dichlorobenzenesulphonyl chloride

cycloleucine methyl ester

8-hydroxy-2,4-dimethylquinoline

2,4-Dichloro-3-methylbenzenesulfonyl chloride

Downstream raw materials:

{4-benzyloxycarbonylamino-1-[2-(4-{1-[2,4-dichloro-3-(2,4-dimethyl-quinolin-8-yloxymethyl)-benzenesulfonylamino]-cyclopentanecarbonyl}-piperazin-1-yl)-2-oxo-ethyl]-butyl}-trimethyl-ammonium

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