carbonic acid pentafluorophenyl ester 3-trifluoromethyl-oxetan-3-yl ester

Base Information

• Chemical Name: carbonic acid pentafluorophenyl ester 3-trifluoromethyl-oxetan-3-yl ester
• CAS No.: 1272974-23-8
• Molecular Formula: C₁₁H₄F₈O₄
• Molecular Weight: 352.138

Synonyms:carbonic acid pentafluorophenyl ester 3-trifluoromethyl-oxetan-3-yl ester

Chemical Property of carbonic acid pentafluorophenyl ester 3-trifluoromethyl-oxetan-3-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of carbonic acid pentafluorophenyl ester 3-trifluoromethyl-oxetan-3-yl ester

There total 2 articles about carbonic acid pentafluorophenyl ester 3-trifluoromethyl-oxetan-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

oxetan-3-one (6704-31-0) + bis(pentafluorophenyl)carbonate (59483-84-0) + (trifluoromethyl)trimethylsilane (81290-20-2) → carbonic acid pentafluorophenyl ester 3-trifluoromethyl-oxetan-3-yl ester (1272974-23-8)

Guidance literature:

oxetan-3-one; (trifluoromethyl)trimethylsilane; With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 2h; Inert atmosphere;

bis(pentafluorophenyl)carbonate; With triethylamine; In acetonitrile; at 0 - 20 ℃; for 18h; Inert atmosphere;

Reference yield: 49.1%

bis(pentafluorophenyl)carbonate (59483-84-0) + 3-(trifluoromethyl)oxetan-3-ol (1403676-72-1) → carbonic acid pentafluorophenyl ester 3-trifluoromethyl-oxetan-3-yl ester (1272974-23-8)

Guidance literature:

With triethylamine; In tetrahydrofuran; acetonitrile; at 0 - 20 ℃; for 23h; Inert atmosphere;

Reference yield: 94.7%

carbonic acid pentafluorophenyl ester 3-trifluoromethyl-oxetan-3-yl ester (1272974-23-8) + 3-((1r,4r)-4-(piperidin-4-yloxy)cyclohexyloxy)pyrazine-2-carbonitrile hydrochloride → 3-(trifluoromethyl)oxetan-3-yl 4-((1r,4r)-4-(3-cyanopyrazin-2-yloxy)cyclohexyloxy)piperidine-1-carboxylate

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 2h; Inert atmosphere;

upstream raw materials:

oxetan-3-one

bis(pentafluorophenyl)carbonate

(trifluoromethyl)trimethylsilane

3-(trifluoromethyl)oxetan-3-ol

Downstream raw materials:

3-(trifluoromethyl)oxetan-3-yl (3R)-4-[5-({2-fluoro-4-[(methylsulfonyl)methyl]benzyl}oxy)pyrimidin-2-yl]-3-methylpiperazine-1-carboxylate

3-(trifluoromethyl)oxetan-3-yl 4-((1r,4r)-{4-[(3-cyanopyridin-4-yl)oxy]cyclohexyl}oxy)piperidine-1-carboxylate

(R)-3-(trifluoromethyl)oxetan-3-yl 4-(5-(2-fluoro-4-(methylsulfonyl)benzyloxy)pyrimidin-2-yl)-3-methylpiperazine-1-carboxylate

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1272974-23-8 carbonic acid pentafluorophenyl ester 3-trifluoromethyl-oxetan-3-yl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send