N⁴-(2-bromo-4-isopropylphenyl)-N⁶-(cyclopropylmethyl)-2-methyl-5-(methylthio)-N⁶-propylpyrimidine-4,6-diamine

Base Information

• Chemical Name: N⁴-(2-bromo-4-isopropylphenyl)-N⁶-(cyclopropylmethyl)-2-methyl-5-(methylthio)-N⁶-propylpyrimidine-4,6-diamine
• CAS No.: 1606178-40-8
• Molecular Formula: C₂₂H₃₁BrN₄S
• Molecular Weight: 463.485

Synonyms:N⁴-(2-bromo-4-isopropylphenyl)-N⁶-(cyclopropylmethyl)-2-methyl-5-(methylthio)-N⁶-propylpyrimidine-4,6-diamine

Chemical Property of N⁴-(2-bromo-4-isopropylphenyl)-N⁶-(cyclopropylmethyl)-2-methyl-5-(methylthio)-N⁶-propylpyrimidine-4,6-diamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N⁴-(2-bromo-4-isopropylphenyl)-N⁶-(cyclopropylmethyl)-2-methyl-5-(methylthio)-N⁶-propylpyrimidine-4,6-diamine

There total 5 articles about N⁴-(2-bromo-4-isopropylphenyl)-N⁶-(cyclopropylmethyl)-2-methyl-5-(methylthio)-N⁶-propylpyrimidine-4,6-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.4%

N-(n-propyl)-N-(cyclopropanemethyl)amine (26389-60-6) + N-(2-bromo-4-isopropylphenyl)-6-chloro-2-methyl-5-(methylthio)pyrimidin-4-amine (1606178-64-6) → N4-(2-bromo-4-isopropylphenyl)-N6-(cyclopropylmethyl)-2-methyl-5-(methylthio)-N6-propylpyrimidine-4,6-diamine (1606178-40-8)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; XPhos; at 100 ℃; Inert atmosphere;

DOI:10.1016/j.ejmech.2014.03.040

Reference yield:

2-bromo-4-isopropylphenylisothiocyanate (246166-33-6) → N4-(2-bromo-4-isopropylphenyl)-N6-(cyclopropylmethyl)-2-methyl-5-(methylthio)-N6-propylpyrimidine-4,6-diamine (1606178-40-8)

Guidance literature:

Multi-step reaction with 5 steps

1.1: triethylamine; sulfur / dimethyl sulfoxide / 0.17 h / 20 °C / Inert atmosphere

1.2: 4 h / 20 °C / Inert atmosphere

2.1: Reflux; Inert atmosphere

3.1: sodium hydroxide / 100 °C / Inert atmosphere

3.2: 2 h / 20 °C / Inert atmosphere

4.1: trichlorophosphate / Inert atmosphere; Reflux

5.1: caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / 100 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; sulfur; triethylamine; sodium hydroxide; XPhos; trichlorophosphate; In dimethyl sulfoxide; 1.1: |Gewald Aminoheterocycles Synthesis / 1.2: |Gewald Aminoheterocycles Synthesis;

DOI:10.1016/j.ejmech.2014.03.040

Reference yield:

4-amino-3-(2-bromo-4-isopropylphenyl)-2-thioxo-2,3-dihydrothiazole-5-carboxamide (228254-23-7) → N4-(2-bromo-4-isopropylphenyl)-N6-(cyclopropylmethyl)-2-methyl-5-(methylthio)-N6-propylpyrimidine-4,6-diamine (1606178-40-8)

Guidance literature:

Multi-step reaction with 4 steps

1.1: Reflux; Inert atmosphere

2.1: sodium hydroxide / 100 °C / Inert atmosphere

2.2: 2 h / 20 °C / Inert atmosphere

3.1: trichlorophosphate / Inert atmosphere; Reflux

4.1: caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / 100 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; sodium hydroxide; XPhos; trichlorophosphate;

DOI:10.1016/j.ejmech.2014.03.040

upstream raw materials:

2-bromo-4-isopropylphenylisothiocyanate

N-(n-propyl)-N-(cyclopropanemethyl)amine

N-(2-bromo-4-isopropylphenyl)-6-chloro-2-methyl-5-(methylthio)pyrimidin-4-amine

4-amino-3-(2-bromo-4-isopropylphenyl)-2-thioxo-2,3-dihydrothiazole-5-carboxamide

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1606178-40-8 N⁴-(2-bromo-4-isopropylphenyl)-N⁶-(cyclopropylmethyl)-2-methyl-5-(methylthio)-N⁶-propylpyrimidine-4,6-diamine

Send

Send

Metric Ton KG G Pound L ML

Send

Send