6-[3-({4-[(1-aminocyclopentyl)carbonyl]piperazin-1-yl}carbonyl)-4-fluorobenzyl]-4,5-dimethylpyridazin-3(2H)-one

Base Information

Chemical Name:6-[3-({4-[(1-aminocyclopentyl)carbonyl]piperazin-1-yl}carbonyl)-4-fluorobenzyl]-4,5-dimethylpyridazin-3(2H)-one
CAS No.:959841-26-0
Molecular Formula:C₂₄H₃₀FN₅O₃
Molecular Weight:455.532
Hs Code.:

Synonyms:6-[3-({4-[(1-aminocyclopentyl)carbonyl]piperazin-1-yl}carbonyl)-4-fluorobenzyl]-4,5-dimethylpyridazin-3(2H)-one

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Chemical Property of 6-[3-({4-[(1-aminocyclopentyl)carbonyl]piperazin-1-yl}carbonyl)-4-fluorobenzyl]-4,5-dimethylpyridazin-3(2H)-one

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Technology Process of 6-[3-({4-[(1-aminocyclopentyl)carbonyl]piperazin-1-yl}carbonyl)-4-fluorobenzyl]-4,5-dimethylpyridazin-3(2H)-one

There total 6 articles about 6-[3-({4-[(1-aminocyclopentyl)carbonyl]piperazin-1-yl}carbonyl)-4-fluorobenzyl]-4,5-dimethylpyridazin-3(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 959841-73-7
tert-Butyl (2R)-2-[(4-{5-[(4,5-dimethyl-6-oxo-1,6-dihydropyridazin-3-yl)methyl]-2-fluorobenzoyl}piperazin-1-yl)carbonyl]-2-methylazetidine-1-carboxylate

: 35264-09-6
1-(tert-butoxycarbonylamino)cyclopentanecarboxylic acid

: 959841-26-0
6-[3-({4-[(1-aminocyclopentyl)carbonyl]piperazin-1-yl}carbonyl)-4-fluorobenzyl]-4,5-dimethylpyridazin-3(2H)-one

Guidance literature:: With benzotriazol-1-ol;

Reference yield:

: 959840-11-0
6-[4-fluoro-3-(piperazin-1-ylcarbonyl)benzyl]-4,5-dimethylpyridazin-3(2H)-one

: 35264-09-6
1-(tert-butoxycarbonylamino)cyclopentanecarboxylic acid

: 959841-26-0
6-[3-({4-[(1-aminocyclopentyl)carbonyl]piperazin-1-yl}carbonyl)-4-fluorobenzyl]-4,5-dimethylpyridazin-3(2H)-one

Guidance literature:: 1-(tert-butoxycarbonylamino)cyclopentanecarboxylic acid; With benzotriazol-1-ol; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

6-[4-fluoro-3-(piperazin-1-ylcarbonyl)benzyl]-4,5-dimethylpyridazin-3(2H)-one; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 - 40 ℃; for 48h; Product distribution / selectivity;

Reference yield:

: 959841-64-6
5-[(4,5-dimethyl-6-oxo-1,6-dihydropyridazin-3-yl)methyl]-2-fluorobenzoic acid

: 959841-26-0
6-[3-({4-[(1-aminocyclopentyl)carbonyl]piperazin-1-yl}carbonyl)-4-fluorobenzyl]-4,5-dimethylpyridazin-3(2H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine / water; N,N-dimethyl-formamide; acetonitrile

2: hydrogenchloride; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide

3: benzotriazol-1-ol

With hydrogenchloride; benzotriazol-1-ol; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In water; N,N-dimethyl-formamide; acetonitrile;