methyl 3-[2-(4-chlorophenoxy)phenyl]-3-hydroxy-2-methylenepropanoate

Base Information

• Chemical Name: methyl 3-[2-(4-chlorophenoxy)phenyl]-3-hydroxy-2-methylenepropanoate
• CAS No.: 1290052-63-9
• Molecular Formula: C₁₇H₁₅ClO₄
• Molecular Weight: 318.757
• Mol file: 1290052-63-9.mol

Synonyms:methyl 3-[2-(4-chlorophenoxy)phenyl]-3-hydroxy-2-methylenepropanoate

Chemical Property of methyl 3-[2-(4-chlorophenoxy)phenyl]-3-hydroxy-2-methylenepropanoate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of methyl 3-[2-(4-chlorophenoxy)phenyl]-3-hydroxy-2-methylenepropanoate

There total 3 articles about methyl 3-[2-(4-chlorophenoxy)phenyl]-3-hydroxy-2-methylenepropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) + 2-(4-chlorophenoxy)benzaldehyde (111826-11-0) → methyl 3-[2-(4-chlorophenoxy)phenyl]-3-hydroxy-2-methylenepropanoate (1290052-63-9)

Guidance literature:

With 1,4-diaza-bicyclo[2.2.2]octane; triethanolamine; at 20 ℃; for 63h;

DOI:10.1055/s-0030-1258392

Reference yield:

4-chloro-phenol (106-48-9,82344-39-6) → methyl 3-[2-(4-chlorophenoxy)phenyl]-3-hydroxy-2-methylenepropanoate (1290052-63-9)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl acetamide / 170 °C

2: 1,4-diaza-bicyclo[2.2.2]octane; triethanolamine / 63 h / 20 °C

With 1,4-diaza-bicyclo[2.2.2]octane; triethanolamine; potassium carbonate; In N,N-dimethyl acetamide; 2: Morita-Baylis-Hillman reaction;

DOI:10.1055/s-0030-1258392

Reference yield:

2-Fluorobenzaldehyde (446-52-6) → methyl 3-[2-(4-chlorophenoxy)phenyl]-3-hydroxy-2-methylenepropanoate (1290052-63-9)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl acetamide / 170 °C

2: 1,4-diaza-bicyclo[2.2.2]octane; triethanolamine / 63 h / 20 °C

With 1,4-diaza-bicyclo[2.2.2]octane; triethanolamine; potassium carbonate; In N,N-dimethyl acetamide; 2: Morita-Baylis-Hillman reaction;

DOI:10.1055/s-0030-1258392

upstream raw materials:

4-chloro-phenol

2-Fluorobenzaldehyde

acrylic acid methyl ester

2-(4-chlorophenoxy)benzaldehyde

Downstream raw materials:

(Z)-methyl 2-bromomethyl-3-[2-(4-chlorophenoxy)phenyl]propenoate