(2S)-1-[(4-fluorophenyl)sulfonyl]-N₂-(2-hydroxypropyl)-2-piperidinecarboxamide

Base Information

• Chemical Name: (2S)-1-[(4-fluorophenyl)sulfonyl]-N₂-(2-hydroxypropyl)-2-piperidinecarboxamide
• CAS No.: 242459-91-2
• Molecular Formula: C₁₅H₂₁FN₂O₄S
• Molecular Weight: 344.407

Synonyms:(2S)-1-[(4-fluorophenyl)sulfonyl]-N₂-(2-hydroxypropyl)-2-piperidinecarboxamide

Chemical Property of (2S)-1-[(4-fluorophenyl)sulfonyl]-N₂-(2-hydroxypropyl)-2-piperidinecarboxamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2S)-1-[(4-fluorophenyl)sulfonyl]-N₂-(2-hydroxypropyl)-2-piperidinecarboxamide

There total 1 articles about (2S)-1-[(4-fluorophenyl)sulfonyl]-N₂-(2-hydroxypropyl)-2-piperidinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-Amino-1-propanol (6168-72-5) + (3-dimethylminopropyl)-3-ethylcarbodiimide + (S)-1-(4-fluorobenzenesulfonyl)piperidine-2-carboxylic acid (242459-61-6,475041-04-4) + 1-hydroxybenzotriazol-hydrate (80029-43-2,123333-53-9) → (2S)-1-[(4-fluorophenyl)sulfonyl]-N2-(2-hydroxypropyl)-2-piperidinecarboxamide (242459-91-2)

Guidance literature:

With 4-methyl-morpholine;

Reference yield:

(2S)-1-[(4-fluorophenyl)sulfonyl]-N2-(2-hydroxypropyl)-2-piperidinecarboxamide (242459-91-2) + Dess-Martin periodane (87413-09-0) → (2S)-1-[(4-fluorophenyl)sulfonyl]-N2-(2-oxopropyl)-2-piperidinecarboxamide (242459-92-3)

Guidance literature:

With triethylamine; In dichloromethane;

upstream raw materials:

2-Amino-1-propanol

(S)-1-(4-fluorobenzenesulfonyl)piperidine-2-carboxylic acid

1-hydroxybenzotriazol-hydrate

Downstream raw materials:

(2S)-1-[(4-fluorophenyl)sulfonyl]-N₂-(2-oxopropyl)-2-piperidinecarboxamide

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