6168-72-5

Basic information

• Product Name: DL-Alaninol
• Synonyms: (+)-2-Aminopropan-1-ol;2-AMINOPROPANOL;H-ALA-OL;H-ALANINOL;H-ALA-OL S-(+)-2 AMINO-PROPANOL;H-L-ALA-OL;L-ALANILOL;L-(+)-2-AMINO PROPANOL
• CAS NO: 6168-72-5
• Molecular Formula: C₃H₉NO
• Molecular Weight: 75.11
• EINECS: 220-388-7
• Product Categories: Amino Alcohols;Building Blocks;Chemical Synthesis;Organic Building Blocks;Oxygen Compounds;API
• Mol File: 6168-72-5.mol
• Article Data: 35

Chemical Properties

• Melting Point: 8°C
• Boiling Point: 72-73 °C11 mm Hg(lit.)
• Flash Point: 145 °F
• Appearance: Clear colorless to light yellow/Viscous Liquid
• Density: 0.943 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.373mmHg at 25°C
• Refractive Index: n20/D 1.450
• Storage Temp.: 2-8°C
• Solubility: Chloroform, Methanol (Slightly)
• PKA: pK1: 9.469(+1) (25°C)
• Water Solubility: soluble
• Sensitive: Air Sensitive & Hygroscopic
• Merck: 14,468
• BRN: 1209234
• CAS DataBase Reference: DL-Alaninol(CAS DataBase Reference)
• NIST Chemistry Reference: DL-Alaninol(6168-72-5)
• EPA Substance Registry System: DL-Alaninol(6168-72-5)

Safety Data

• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-36/37/39-45
• RIDADR: UN 2735 8/PG 2
• WGK Germany: 3
• F: 10-23
• TSCA: Yes
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 6168-72-5(Hazardous Substances Data)

Usage

Uses

DL-Alaninol has been used in the synthesis of N6-α-(I-hydroxypropyl) lysine, diastereomers of DL-β-amino alcohols, enantiopure and racemic samples of 2-methyl-N-tosylaziridine, (±)-3-(5-dimethylcarbamoyl-pent-1-enyl)-N-(2-hydroxy-1-methyl-ethyl)benzamide.

General Description

A colorless to pale yellow liquid with a fishy odor. Moderately toxic by ingestion and skin contact. A severe skin irritant. Combustible. The compound contains both the amine group -NH2 and the alcohol group -OH and so has some properties of both. Floats and mixes with water.

Reactivity Profile

DL-Alaninol is a chemical base. Neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides.

InChI:InChI=1/C3H9NO/c1-3(4)2-5/h3,5H,2,4H2,1H3/p+1/t3-/m1/s1

Synthetic route

2-NITROPROPANOL (2902-96-7) → 2-Amino-1-propanol (6168-72-5)

Conditions	Yield
With trichlorosilane; N-ethyl-N,N-diisopropylamine In acetonitrile at 15℃; for 30h;	100%
With trichlorosilane; N-ethyl-N,N-diisopropylamine In acetonitrile at 0 - 20℃; for 18h; Inert atmosphere;	90%
With ethanol; nickel Hydrogenation;
With methanol; nickel Hydrogenation;
With hydrogen; palladium on activated charcoal In ethanol under 2280 Torr;

formaldehyd (50-00-0) + Nitroethane (79-24-3) → 2-Amino-1-propanol (6168-72-5)

Conditions	Yield
Stage #1: formaldehyd; Nitroethane With triethanolamine In water at 50℃; for 105h; Stage #2: With Fe/Ni; hydrogen at 70℃; under 22502.3 Torr; for 4h; Reagent/catalyst; Temperature; Pressure;	82.6%

hydroxy-2-propanone (116-09-6) → 2-Amino-1-propanol (6168-72-5)

Conditions	Yield
Stage #1: hydroxy-2-propanone With ammonia In water at 0 - 20℃; for 1 - 1.5h; Stage #2: With hydrogen; nickel In water at 85℃; under 57647.8 Torr; Product distribution / selectivity;	71.5%
Stage #1: hydroxy-2-propanone With ammonia at 20℃; for 1h; Stage #2: With hydrogen; nickel at 85℃; under 57647.8 Torr; Product distribution / selectivity;	33.4%
Stage #1: hydroxy-2-propanone With ammonia In water at 20℃; for 1.5h; Stage #2: With hydrogen; Nickel Raney 5886 In water at 85℃; under 23252.3 Torr; for 0.166667 - 0.333333h; Product distribution / selectivity;
Stage #1: hydroxy-2-propanone With ammonia In water at 20℃; for 1.5h; Stage #2: With hydrogen; nickel oxide on kieselguhr In water at 85℃; under 25877.6 - 113786 Torr; Product distribution / selectivity;
With (S)-1-phenyl-ethylamine; pyridoxal 5'-phosphate; pQR1108 In aq. phosphate buffer; dimethyl sulfoxide at 30℃; for 18h; pH=8; Enzymatic reaction;

rac-Ala-OH (302-72-7) → 2-Amino-1-propanol (6168-72-5)

Conditions	Yield
With sodium tetrahydroborate; iodine In tetrahydrofuran for 15h; Heating;	60%
With dimethylsulfide borane complex; boron trifluoride diethyl etherate In tetrahydrofuran for 2.5h; Heating;
Stage #1: rac-Ala-OH With lithium aluminium tetrahydride In tetrahydrofuran for 12h; Reflux; Stage #2: With sodium hydroxide In tetrahydrofuran; water at 0 - 20℃;

ethyl pyruvate oxime (120586-56-3, 20591-87-1) → 2-Amino-1-propanol (6168-72-5)

Conditions	Yield
With sodium tetrahydroborate; iodine In tetrahydrofuran for 4h; Heating;	60%

AlaOEt (17344-99-9) → 2-Amino-1-propanol (6168-72-5)

Conditions	Yield
With ethanol; nickel at 50 - 100℃; Hydrogenation;

dl-alanylglycine (1188-01-8) → 2-Amino-1-propanol (6168-72-5)

Conditions	Yield
With ethanol; sodium

ethyl 2-acetamidopropanoate (5143-72-6) → 2-Amino-1-propanol (6168-72-5)

Conditions	Yield
With ethanol; sodium

1-hydroxy-2-propanone oxime (134252-16-7) → 2-Amino-1-propanol (6168-72-5) + isopropylamine (75-31-0)

Conditions	Yield
With sodium amalgam; acetic acid

β-chloro-isobutyric acid amide (7476-61-1) → 2-Amino-1-propanol (6168-72-5)

Conditions	Yield
With alkaline aqueous sodium hypobromite

hydroxy-2-propanone (116-09-6) → 2,5-dimethoxy-2,5-dimethyl-1,4-dioxane (7504-90-7) + 2-Amino-1-propanol (6168-72-5)

Conditions	Yield
With methanol; ammonia; water; nickel at 90℃; under 11032.6 Torr; Hydrogenation;

2-amino-2-[1,3]dithiolan-2-yl-ethanol (24401-53-4) → 2-Amino-1-propanol (6168-72-5)

Conditions	Yield
With nickel

methyl 2-aminopropanoate monohydrochloride (13515-97-4) → 2-Amino-1-propanol (6168-72-5)

Conditions	Yield
With lithium aluminium tetrahydride

propylamine (107-10-8) → 2-Amino-1-propanol (6168-72-5) + (RS)-isoserine (632-12-2) + glycine (56-40-6) + propan-1-ol-3-amine (156-87-6) + 3-amino propanoic acid (107-95-9)

Conditions	Yield
In water at 10 - 20℃; Product distribution; pH=2.7 and pH=12.0, various reaction times, contact glow discharge electrolysis;

propylamine (107-10-8) → 2-Amino-1-propanol (6168-72-5) + (RS)-isoserine (632-12-2) + glycine (56-40-6) + 3-amino propanoic acid (107-95-9)

Conditions	Yield
In water at 10 - 20℃; contact glow discharge electrolysis; Yield given. Further byproducts given. Yields of byproduct given;
In water at 10 - 20℃; contact glow discharge electrolysis, pH=2.7; Yield given. Further byproducts given. Yields of byproduct given;
In water at 10 - 20℃; contact glow discharge electrolysis, pH=2.7; Yield given. Further byproducts given;

N-chloro-2-aminopropan-1-ol (124236-93-7) → 2-Amino-1-propanol (6168-72-5)

Conditions	Yield
With disodium hydrogenphosphate; sodium dihydrogenphosphate; sodium perchlorate; sodium iodide Thermodynamic data; Kinetics; Rate constant; Ea, ΔH, ΔS, influence of pH on the rate constant, reaction mechanism;

2-((S)-1-Phenyl-ethylamino)-propan-1-ol → 2-Amino-1-propanol (6168-72-5)

Conditions	Yield
With hydrogen S, Ram, L. D. Spicer Synth. Commun. 1987, 17, 415.;

ammonia (7664-41-7) + hydroxy-2-propanone (116-09-6) → 2,5-dimethoxy-2,5-dimethyl-1,4-dioxane (7504-90-7) + 2-Amino-1-propanol (6168-72-5)

Conditions	Yield
und anschliessenden Hydrierung an Raney-Nickel bei 80grad/15 at;

tetrahydrofuran (109-99-9) + N-(N-benzoyl-glycyl)-alanine ethyl ester (24639-12-1) + LiBH4 → 2-Amino-1-propanol (6168-72-5) + ethanolamine (141-43-5)

hydroxy-2-propanone (116-09-6) → 2-Amino-1-propanol (6168-72-5) + propylene glycol (57-55-6)

Conditions	Yield
Stage #1: hydroxy-2-propanone With ammonia In water at 20℃; for 1.5h; Stage #2: With hydrogen; nickel In water at 85℃; under 113786 Torr; Product distribution / selectivity;
With ammonia; hydrogen; Nickel Raney 5886 at 85℃; under 23252.3 Torr; Product distribution / selectivity;

C19H17Cl4N2O5Pol → 2-Amino-1-propanol (6168-72-5) + C17H9Cl4F3NO4Pol

Conditions	Yield
With trifluoroacetic acid polystyrene ((aminomethyl)polystyrene); Product distribution / selectivity;

glycerol (56-81-5) → piperazine (110-85-0) + propylamine (107-10-8) + 2-Amino-1-propanol (6168-72-5) + N-(1-aminomethyl-2-hydroxyethyl)amine (2811-20-3) + (RS)-2-methylpiperazine (109-07-9) + ethylamine (75-04-7) + isopropylamine (75-31-0) + 1,2-diaminopropan (78-90-0, 10424-38-1) + 3-amino-2-propanol (78-96-6, 1674-56-2) + methylamine (74-89-5)

Conditions

Yield

With ammonia; hydrogen; catalyst obtained by prereduction from precursor whose catalytically active composition before the reduction with hydrogen comprised 13% by weight of Cu, calculated as CuO, 28% by weight of NI, calculated as NiO, 28% by weight of Co, calculated as CoO and 31% by weight of Zr, calculated as ZrO2 In water at 250℃; under 37503.8 - 225023 Torr; Product distribution / selectivity; Autoclave;

...Expand

glycerol (56-81-5) → 2-Amino-1-propanol (6168-72-5) + N-(1-aminomethyl-2-hydroxyethyl)amine (2811-20-3) + 1,2,3-triaminopropane (21291-99-6) + (RS)-2-methylpiperazine (109-07-9) + 1,2-diaminopropan (78-90-0, 10424-38-1) + 2,6-dimethylpiperazine (108-49-6) + 2,5-dimethylpiperazine (106-55-8)

Conditions	Yield
With ammonia; hydrogen; catalyst precursor whose active composition comprised 13% by weight of Cu, calculated as CuO, 28% by weight of Ni, calculated as NiO, 28% by weight of Co, calculated as CoO and 31% by weight of Zr, calculated as ZrO2 In water at 180℃; under 150015 Torr; for 53h; Product distribution / selectivity;

glycerol (56-81-5) → 2-Amino-1-propanol (6168-72-5) + N-(1-aminomethyl-2-hydroxyethyl)amine (2811-20-3) + 1,2,3-triaminopropane (21291-99-6) + 2-aminomethyl-6-methylpiperazine (1122585-40-3) + 2,5-bis(aminomethyl)piperazine (1122585-41-4) + 2-aminomethylpiperazine (130861-85-7) + 2-aminomethyl-5-methylpiperazine (136665-35-5) + (RS)-2-methylpiperazine (109-07-9) + 1,2-diaminopropan (78-90-0, 10424-38-1) + 2,6-dimethylpiperazine (108-49-6) + 2,5-dimethylpiperazine (106-55-8)

Conditions	Yield
With ammonia; hydrogen; catalyst precursor whose active composition comprised 50% by weight of Ni, calculated as NiO, 18% by weight of Cu, calculated as CuO, 2% by weight of Mo, calculated as MoO3, and 30% by weight or Zr, calculated as ZrO2 In water at 192℃; under 150015 Torr; for 1076h; Product distribution / selectivity;

...Expand

glycerol (56-81-5) → propan-1-ol (71-23-8) + 2-Amino-1-propanol (6168-72-5) + 3-amino-2-propanol (78-96-6, 1674-56-2) + isopropyl alcohol (67-63-0)

Conditions	Yield
With ammonia; hydrogen In water at 20℃; under 37503.8 Torr; for 24h;

2-Amino-1-propanol (6168-72-5) + N-methyl-N-tert-butyldimethylsilyl-1,1,1-trifluoroacetamide (77377-52-7) → (tert-Butyl-dimethyl-silanyl)-[2-(tert-butyl-dimethyl-silanyloxy)-1-methyl-ethyl]-amine (82134-49-4)

Conditions	Yield
With tert-butyldimethylsilyl chloride In acetonitrile for 0.0833333h; Ambient temperature; other silylating agent;	100%

phthalic anhydride (85-44-9) + 2-Amino-1-propanol (6168-72-5) → 2-(2-hydroxy-1-methylethyl)-1H-isoindole-1,3(2H)-dione (211501-36-9)

Conditions	Yield
With triethylamine In toluene Reflux;	100%
In toluene	100%
With triethylamine In toluene for 3h; Condensation; Heating;	95%

2-Amino-1-propanol (6168-72-5) + ethyl trifluoroacetate, (383-63-1) → 2,2,2-trifluoro-N-(2-hydroxy-1-methyl-ethyl)-acetamide

Conditions	Yield
In acetonitrile	100%

2-Amino-1-propanol (6168-72-5) + m-bromobenzoic aldehyde (3132-99-8) → C10H12BrNO

Conditions	Yield
In methanol at 20℃; for 1h;	100%

2-Amino-1-propanol (6168-72-5) + 2-fluoro-4-[4-(4-fluorophenyl)-1-(2-methoxyethyl)-2-(methylsulfanyl)-1H-imidazol-5-yl]pyridine (908381-35-1) → 2-{4-[4-(4-fluorophenyl)-3-(2-methoxyethyl)-2-methylsulfanyl-1H-imidazol-5-yl]pyridin-2-ylamino}-propan-1-ol

Conditions	Yield
at 155℃; for 19h;	100%
In ethyl acetate at 155℃; for 19h;	99.7%

2-Amino-1-propanol (6168-72-5) + tert-butyldimethylsilyl chloride (18162-48-6) → 1-(tert-butyldimethylsilyloxy)propan-2-amine (175718-35-1)

Conditions	Yield
With 1H-imidazole In dichloromethane at 20℃; for 4h;	100%

2-Amino-1-propanol (6168-72-5) + 3-nitro-benzeneacetic acid (1877-73-2) → N-(1-hydroxypropan-2-yl)-2-(3-nitrophenyl)acetamide (1308256-50-9)

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide for 16h;	100%

2-Amino-1-propanol (6168-72-5) + Diethyl carbonate (105-58-8) → 4-methyl-2-oxazolidone (16112-59-7)

Conditions	Yield
With sodium ethanolate at 125℃; for 5h;	99%
With potassium carbonate at 130℃; for 3h;	73%
With sodium methylate for 4h;
With sodium methylate
With sodium methylate In methanol at 20℃; Heating / reflux;

2-Amino-1-propanol (6168-72-5) + propynoic acid ethyl ester (623-47-2) → (+)Ethyl 3-[(1-hydroxyprop-2(S)-yl)amino]acrylate

Conditions	Yield
In acetonitrile	99%

2-Amino-1-propanol (6168-72-5) + methyl [6-(3-fluoro-4-methoxybenzyl)-1,2,4,7-tetrahydro-3H-indolo[2,3-c][1,7]naphthyridin-3-yl]acetate (1207632-41-4) → 2-[6-(3-fluoro-4-methoxybenzyl)-1,2,4,7-tetrahydro-3H-indolo[2,3-c][1,7]naphthyridin-3-yl]-N-(2-hydroxy-1-methylethyl)acetamide (1207632-49-2)

Conditions	Yield
at 100℃; for 18h;	99%

2-Amino-1-propanol (6168-72-5) + cis-5-tert-butoxycarbonyltetrahydro-3aH-furo[3,4-c]pyrrole-1,3-dione (441298-22-2) → C14H22N2O5 (1221289-94-6)

Conditions	Yield
In toluene at 170℃; for 0.233333h; Microwave irradiation;	99%

2-Amino-1-propanol (6168-72-5) + pentan-3-one (96-22-0) → 2,2-Diethyl-4-methyl-oxazolidine (146377-27-7)

Conditions	Yield
at 50℃; for 3h;	98%

2-Amino-1-propanol (6168-72-5) + phenyl isothiocyanate (103-72-0) → 1-(1-hydroxypropan-2-yl)-3-phenylthiourea (21152-53-4)

Conditions	Yield
In tetrahydrofuran at 20℃; for 0.5h; Alkylation;	98%
In tetrahydrofuran at 20℃;

2-Amino-1-propanol (6168-72-5) + 2-fluorobenzonitrile (394-47-8) → 2-(2-aminopropoxy)benzonitrile hydrochloride

Conditions	Yield
Stage #1: 2-Amino-1-propanol; 2-fluorobenzonitrile With potassium tert-butylate In tetrahydrofuran at 0 - 25℃; Stage #2: With hydrogenchloride In tetrahydrofuran; 2-methyltetrahydrofuran; 1,4-dioxane	97%

2-Amino-1-propanol (6168-72-5) + di-tert-butyl dicarbonate (24424-99-5) → tert-butyl (1-hydroxypropan-2-yl)carbamate (147252-84-4, 79069-13-9, 106391-86-0, 127516-56-7)

Conditions	Yield
With sodium hydroxide In tetrahydrofuran; water at 20℃; for 14h;	96%
In dichloromethane at 20℃; for 1h;	93%
With triethylamine In dichloromethane at 20℃; for 0.5h; Cooling with ice;	90.7%

2-Amino-1-propanol (6168-72-5) + carbon monoxide (201230-82-2) → 4-methyl-2-oxazolidone (16112-59-7)

Conditions	Yield
With oxygen; potassium iodide; palladium(II) iodide In 1,2-dimethoxyethane at 100℃; under 15201 Torr; for 15h;	96%
With oxygen; sodium iodide; salen-Co(II) complex In 1,4-dioxane at 120℃; under 45004.5 Torr; for 2h;	96%
With oxygen; potassium iodide; palladium(II) iodide at 100℃; under 15001.5 Torr; for 24h; Autoclave;	94%

2-Amino-1-propanol (6168-72-5) + 3-chloro-4-fluorobenzonitrile (117482-84-5) → 3-chloro-4-(2-hydroxy-1-methyl-ethylamino)-benzonitrile (864297-00-7)

Conditions	Yield
In dimethyl sulfoxide at 60℃; for 2h;	96%
In dimethyl sulfoxide at 60℃; for 2h;	96%

2-Amino-1-propanol (6168-72-5) + benzaldehyde (100-52-7) → (E)-1-(benzylideneamino)propan-2-ol (124948-53-4)

Conditions	Yield
With 3 A molecular sieve for 8h; Ambient temperature;	95%

2-Amino-1-propanol (6168-72-5) + carbon dioxide (124-38-9) → 4-methyl-2-oxazolidone (16112-59-7)

Conditions	Yield
With dentritic zwitterionic imidazolium ionic liquid immobilized on mesoporous silica nanoparticles at 70℃; for 8h; Autoclave;	95%
With nanoparticulated CeO2 In ethanol at 160℃; under 5250.53 Torr; for 8h; Sealed reactor;

2-Amino-1-propanol (6168-72-5) + chloroformic acid ethyl ester (541-41-3) → 2--1-propanol (74877-63-7)

Conditions	Yield
With sodium carbonate In water for 2h; Ambient temperature;	94%
With diethyl ether

2-Amino-1-propanol (6168-72-5) + (fluorenylmethoxy)carbonyl chloride (28920-43-6) → (2-hydroxy-1-methylethyl)carbamic acid 9H-fluoren-9-yl methyl ester (851678-69-8)

Conditions	Yield
In diethyl ether at 20℃; for 2h;	94%

2-Amino-1-propanol (6168-72-5) + urea (57-13-6) → 4-methyl-2-oxazolidone (16112-59-7)

Conditions	Yield
With nitromethane for 0.0833333h; Microwave irradiation;	94%

2-Amino-1-propanol (6168-72-5) + ethyl 3-(2,6-dichloro-5-fluoro-3-pyridyl)-2--3-oxopropionate (127421-81-2) → (+/-)-ethyl 3-(2,6-dichloro-5-fluoro-3-pyridyl)-2-(4-methyloxazolidin-2-ylidene)-3-oxopropionate (127421-83-4)

Conditions	Yield
In toluene for 2.5h; Heating;	93%

2-Amino-1-propanol (6168-72-5) + Cyclohexyl methyl ketone (823-76-7) → 2-Cyclohexyl-2,4-dimethyl-oxazolidine

Conditions	Yield
In benzene at 80℃; for 4h;	93%

2-Amino-1-propanol (6168-72-5) + n-hexadecanoyl chloride (112-67-4) → (S)-2-methyl-2-(N-palmitoylamino)ethanol (107655-52-7)

Conditions	Yield
With triethylamine In chloroform; water	93%

2-Amino-1-propanol (6168-72-5) + p-toluenesulfonyl chloride (98-59-9) → (+/-)-N-<2-hydroxy-1-methylethyl>-p-toluolsulfonamid (114663-10-4)

Conditions	Yield
With triethylamine In dichloromethane at 0 - 20℃;	93%
With triethylamine In dichloromethane at 0 - 20℃; for 18h;	84%
With triethylamine In dichloromethane at 20℃;

2-Amino-1-propanol (6168-72-5) + 2-{6,6-dimethyl-1-[2-(trimethylsilyl)ethoxymethyl]-4,5,6,7-tetrahydro-1H-indazol-3-yl}-1-[2-(trimethylsilyl)ethoxymethyl]-1H-indole-6-carboxylic acid (1309788-61-1) → 2-{6,6-dimethyl-1-[2-(trimethylsilyl)ethoxymethyl]-4,5,6,7-tetrahydro-1H-indazol-3-yl}-1-[2-(trimethylsilyl)ethoxymethyl]-1H-indole-6-carboxylic acid (2-hydroxy-1-methylethyl)amide (1309788-70-2)

Conditions	Yield
With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride In N,N-dimethyl-formamide at 20℃; for 7h;	93%

2-Amino-1-propanol (6168-72-5) + C23H30ClN5O2 → C26H38N6O3

Conditions	Yield
With triethylamine In methanol Reflux;	93%

2-Amino-1-propanol (6168-72-5) + 5-bromo-1,3-difluoro-2-nitro-benzene (147808-42-2) → 2-(5-bromo-3-fluoro-2-nitroanilino)propan-1-ol

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide at 80℃; for 1h;	93%

Upstream product

• 1188-01-8 dl-alanylglycine 
• 5143-72-6 ethyl 2-acetamidopropanoate 
• 134252-16-7 1-hydroxy-2-propanone oxime 
• 7476-61-1 β-chloro-isobutyric acid amide 
• 2902-96-7 2-NITROPROPANOL 
• 116-09-6 hydroxy-2-propanone 
• 24401-53-4 2-amino-2-[1,3]dithiolan-2-yl-ethanol 
• 107-10-8 propylamine 
• 302-72-7 rac-Ala-OH 
• 109-99-9 tetrahydrofuran 
• 24639-12-1 N-(N-benzoyl-glycyl)-alanine ethyl ester 
• 120586-56-3 ethyl pyruvate oxime 
• 56-81-5 glycerol 
• 57-55-6 propylene glycol 

Downstream Products

• 20826-28-2 2-(2,4-dinitro-anilino)-propan-1-ol 
• 24403-02-9 2-isopropylamino-1-propanol 
• 302-72-7 rac-Ala-OH 
• 1908-84-5 (+/-)-sulfuric acid mono-(2-amino-propyl ester) 
• 2815-34-1 2,5-dimethyl-piperazine 
• 6284-84-0 cis-2,5-dimethylpiperazine 
• 60448-81-9 (+/-)-N,N-dibenzyl-2-aminopropan-1-ol 
• 69296-06-6 beta-methyl morpholinoethanol 
• 2294-46-4 bis(2-hydroxy-1-methylethyl)amine 
• 6159-23-5 (R,S)-2,4-dimethyl-2-oxazoline 
• 1437-89-4 4-methyl-thiazolidine-2-thione 
• 56160-88-4 N-{4-chloro-2-[(2-chloro-phenyl)-(2-hydroxy-1-methyl-ethylimino)-methyl]-phenyl}-2-morpholin-4-yl-acetamide 
• 29912-93-4 oxazolam 
• 29441-77-8 4,5,8-trimethyl-3,4-dihydro-2H-benzo[1,4]oxazine-6,7-dione 

Relevant articles and documents

Method for preparing 2-amino propanol

The invention discloses a method for preparing 2-amino propanol. The method comprises the following steps: (1) paraformaldehyde is dissolved in an alcohol amine aqueous solution to form a paraformaldehyde dissolving solution, then the paraformaldehyde dissolving solution is added dropwise into nitroethane to react, settling and separatinglayering are conducted after reaction is ended, unreacted nitroethane is separated through distillation, a product generated after the unreacted nitroethane is separated forms an intermediate product, and the intermediate product contains nitropropanol; (2) ametal catalyst is added in the intermediate product, H is introduced for reaction, and a reaction mixture is obtained after the reaction is completed; and (3) the reaction mixture obtained in the step (2) is filtered, a filtrate is decompressed and rectifiedsubjected to pressure-reduced rectification to obtain the 2-amino propanol. The method for preparing the 2-amino propanol has the advantagescharacteristics that the reaction efficiency is high, the product purity is high, three wastes are less, and the economical efficiency is good, thereby reducing the pollution to the environment.

Selective amination of 1,2-propanediol over Co/La3O4 catalyst prepared by liquid-phase reduction

The catalytic coupling of alcohol and ammonia is an environmentally friendly process. Cobalt-based catalysts, modified by supports (including CeO2, Fe3O4, Nb2O5, La3O4 and Al2O3), and prepared by the liquid-phase reduction, were used for the amination of 1,2-propanediol. The screened nano-Co/La3O4 catalyst exhibited an excellent catalytic performance of 68% conversion and 89% selectivity toward 2-amino-1-propanol under optimal conditions. The characterizations of the catalyst was performed by XRD, XPS, BET, TEM, TG, and CO2-TPD, revealing a relatively large specific surface area, strongly alkaline sites and a Co-La-O transition phase, which were responsible for the selective catalysis of 1,2-propanediol. The efficient construction of cobalt-based catalysts on the basis of the active species is key to improving the efficiency of the reaction process.