N-(tert-butoxycarbonyl)-L-alanyl-L-alanyl-O'-benzyl-L-tyrosine ethyl ester

Base Information

Chemical Name:N-(tert-butoxycarbonyl)-L-alanyl-L-alanyl-O'-benzyl-L-tyrosine ethyl ester
CAS No.:127132-34-7
Molecular Formula:C₂₉H₃₉N₃O₇
Molecular Weight:541.645
Hs Code.:

Synonyms:N-(tert-butoxycarbonyl)-L-alanyl-L-alanyl-O'-benzyl-L-tyrosine ethyl ester

Suppliers and Price of N-(tert-butoxycarbonyl)-L-alanyl-L-alanyl-O'-benzyl-L-tyrosine ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of N-(tert-butoxycarbonyl)-L-alanyl-L-alanyl-O'-benzyl-L-tyrosine ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-(tert-butoxycarbonyl)-L-alanyl-L-alanyl-O'-benzyl-L-tyrosine ethyl ester

There total 6 articles about N-(tert-butoxycarbonyl)-L-alanyl-L-alanyl-O'-benzyl-L-tyrosine ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.3%

: 15761-38-3
L-N-Boc-Ala

: 127132-33-6
L-alanyl-O'-benzyl-L-tyrosine ethyl ester hydrochloride

: 127132-34-7
N-(tert-butoxycarbonyl)-L-alanyl-L-alanyl-O'-benzyl-L-tyrosine ethyl ester

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; for 20h; Ambient temperature;
DOI:10.1021/jm00168a015

Reference yield:

: 949-67-7
L-tyrosine ethyl ester

: 127132-34-7
N-(tert-butoxycarbonyl)-L-alanyl-L-alanyl-O'-benzyl-L-tyrosine ethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 82.6 percent / NaHCO₃ / methanol; tetrahydrofuran / 20 h / Ambient temperature

2: 84 percent / K₂CO₃ / acetone / 6 h / Heating

3: 80 percent / HCl / dioxane / 2 h / Ambient temperature

4: 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride, 1-hydroxybenzotriazole, N-methylmorpholine / dimethylformamide / 20 h / Ambient temperature

5: HCl / dioxane / 2 h / Ambient temperature

6: 65.3 percent / 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride, 1-hydroxybenzotriazole, N-methylmorpholine / dimethylformamide / 20 h / Ambient temperature

With 4-methyl-morpholine; hydrogenchloride; sodium hydrogencarbonate; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm00168a015

Reference yield:

: 72594-77-5,1241680-28-3
N-(tert-butoxycarbonyl)-L-tyrosine ethyl ester

: 127132-34-7
N-(tert-butoxycarbonyl)-L-alanyl-L-alanyl-O'-benzyl-L-tyrosine ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 84 percent / K₂CO₃ / acetone / 6 h / Heating

2: 80 percent / HCl / dioxane / 2 h / Ambient temperature

3: 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride, 1-hydroxybenzotriazole, N-methylmorpholine / dimethylformamide / 20 h / Ambient temperature

4: HCl / dioxane / 2 h / Ambient temperature

5: 65.3 percent / 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride, 1-hydroxybenzotriazole, N-methylmorpholine / dimethylformamide / 20 h / Ambient temperature

With 4-methyl-morpholine; hydrogenchloride; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm00168a015