Technology Process of N-(tert-butoxycarbonyl)-L-alanyl-L-alanyl-L-tyrosine ethyl ester
There total 7 articles about N-(tert-butoxycarbonyl)-L-alanyl-L-alanyl-L-tyrosine ethyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogenchloride; hydrogen;
palladium on activated charcoal;
In
ethanol;
for 0.5h;
under 15200 Torr;
DOI:10.1021/jm00168a015
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 82.6 percent / NaHCO3 / methanol; tetrahydrofuran / 20 h / Ambient temperature
2: 84 percent / K2CO3 / acetone / 6 h / Heating
3: 80 percent / HCl / dioxane / 2 h / Ambient temperature
4: 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride, 1-hydroxybenzotriazole, N-methylmorpholine / dimethylformamide / 20 h / Ambient temperature
5: HCl / dioxane / 2 h / Ambient temperature
6: 65.3 percent / 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride, 1-hydroxybenzotriazole, N-methylmorpholine / dimethylformamide / 20 h / Ambient temperature
7: 76.6 percent / H2, 1 N HCl / Pd/C / ethanol / 0.5 h / 15200 Torr
With
4-methyl-morpholine; hydrogenchloride; hydrogen; sodium hydrogencarbonate; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
palladium on activated charcoal;
In
tetrahydrofuran; 1,4-dioxane; methanol; ethanol; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm00168a015
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 84 percent / K2CO3 / acetone / 6 h / Heating
2: 80 percent / HCl / dioxane / 2 h / Ambient temperature
3: 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride, 1-hydroxybenzotriazole, N-methylmorpholine / dimethylformamide / 20 h / Ambient temperature
4: HCl / dioxane / 2 h / Ambient temperature
5: 65.3 percent / 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride, 1-hydroxybenzotriazole, N-methylmorpholine / dimethylformamide / 20 h / Ambient temperature
6: 76.6 percent / H2, 1 N HCl / Pd/C / ethanol / 0.5 h / 15200 Torr
With
4-methyl-morpholine; hydrogenchloride; hydrogen; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
palladium on activated charcoal;
In
1,4-dioxane; ethanol; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm00168a015