{5-[(7-chloroquinolin-4-yl)amino]-2-morpholinophenyl}methanol hydrochloride

Base Information

Chemical Name:{5-[(7-chloroquinolin-4-yl)amino]-2-morpholinophenyl}methanol hydrochloride
CAS No.:1312291-23-8
Molecular Formula:C₂₀H₂₀ClN₃O₂*ClH
Molecular Weight:406.312
Hs Code.:

Synonyms:{5-[(7-chloroquinolin-4-yl)amino]-2-morpholinophenyl}methanol hydrochloride

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Chemical Property of {5-[(7-chloroquinolin-4-yl)amino]-2-morpholinophenyl}methanol hydrochloride

Chemical Property:

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Technology Process of {5-[(7-chloroquinolin-4-yl)amino]-2-morpholinophenyl}methanol hydrochloride

There total 4 articles about {5-[(7-chloroquinolin-4-yl)amino]-2-morpholinophenyl}methanol hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 759456-60-5
(5-amino-2-morpholinophenyl)methanol

: 86-98-6,1138471-54-1
4,7-dichloroquinoline

: 1312291-23-8
{5-[(7-chloroquinolin-4-yl)amino]-2-morpholinophenyl}methanol hydrochloride

Guidance literature:: In pentan-1-ol; Reflux;
DOI:10.1515/HC.2010.011

Reference yield:

: 27996-87-8
2-fluoro-5-nitrobenzaldehye

: 1312291-23-8
{5-[(7-chloroquinolin-4-yl)amino]-2-morpholinophenyl}methanol hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

2: 1 h / 130 °C

3: palladium 10% on activated carbon; ammonium formate / ethanol / 20 °C

4: pentan-1-ol / Reflux

With palladium 10% on activated carbon; ammonium formate; In ethanol; pentan-1-ol;
DOI:10.1515/HC.2010.011

Reference yield:

: 63878-73-9
(2-fluoro-5-nitrophenyl)methanol

: 1312291-23-8
{5-[(7-chloroquinolin-4-yl)amino]-2-morpholinophenyl}methanol hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: 1 h / 130 °C

2: palladium 10% on activated carbon; ammonium formate / ethanol / 20 °C

3: pentan-1-ol / Reflux

With palladium 10% on activated carbon; ammonium formate; In ethanol; pentan-1-ol;
DOI:10.1515/HC.2010.011