(S)-2-({(S)-2-[(S)-3-(4-Benzyloxy-phenyl)-2-(tert-butoxycarbonyl-methyl-amino)-propionyloxy]-3-methyl-butyryl}-methyl-amino)-3-methyl-butyric acid (S)-2-methyl-1-(2-trimethylsilanyl-ethoxycarbonyl)-propyl ester

Base Information

Chemical Name:(S)-2-({(S)-2-[(S)-3-(4-Benzyloxy-phenyl)-2-(tert-butoxycarbonyl-methyl-amino)-propionyloxy]-3-methyl-butyryl}-methyl-amino)-3-methyl-butyric acid (S)-2-methyl-1-(2-trimethylsilanyl-ethoxycarbonyl)-propyl ester
CAS No.:185448-70-8
Molecular Formula:C₄₃H₆₆N₂O₁₀Si
Molecular Weight:799.09
Hs Code.:

(S)-2-({(S)-2-[(S)-3-(4-Benzyloxy-phenyl)-2-(tert-butoxycarbonyl-methyl-amino)-propionyloxy]-3-methyl-butyryl}-methyl-amino)-3-methyl-butyric acid (S)-2-methyl-1-(2-trimethylsilanyl-ethoxycarbonyl)-propyl ester

Synonyms:(S)-2-({(S)-2-[(S)-3-(4-Benzyloxy-phenyl)-2-(tert-butoxycarbonyl-methyl-amino)-propionyloxy]-3-methyl-butyryl}-methyl-amino)-3-methyl-butyric acid (S)-2-methyl-1-(2-trimethylsilanyl-ethoxycarbonyl)-propyl ester

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Chemical Property of (S)-2-({(S)-2-[(S)-3-(4-Benzyloxy-phenyl)-2-(tert-butoxycarbonyl-methyl-amino)-propionyloxy]-3-methyl-butyryl}-methyl-amino)-3-methyl-butyric acid (S)-2-methyl-1-(2-trimethylsilanyl-ethoxycarbonyl)-propyl ester

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Technology Process of (S)-2-({(S)-2-[(S)-3-(4-Benzyloxy-phenyl)-2-(tert-butoxycarbonyl-methyl-amino)-propionyloxy]-3-methyl-butyryl}-methyl-amino)-3-methyl-butyric acid (S)-2-methyl-1-(2-trimethylsilanyl-ethoxycarbonyl)-propyl ester

There total 6 articles about (S)-2-({(S)-2-[(S)-3-(4-Benzyloxy-phenyl)-2-(tert-butoxycarbonyl-methyl-amino)-propionyloxy]-3-methyl-butyryl}-methyl-amino)-3-methyl-butyric acid (S)-2-methyl-1-(2-trimethylsilanyl-ethoxycarbonyl)-propyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 185448-72-0
(S)-3-Methyl-2-methylamino-butyric acid (S)-2-methyl-1-(2-trimethylsilanyl-ethoxycarbonyl)-propyl ester

: 185448-71-9
(S)-2-[(S)-3-(4-Benzyloxy-phenyl)-2-(tert-butoxycarbonyl-methyl-amino)-propionyloxy]-3-methyl-butyric acid

: 185448-70-8
(S)-2-({(S)-2-[(S)-3-(4-Benzyloxy-phenyl)-2-(tert-butoxycarbonyl-methyl-amino)-propionyloxy]-3-methyl-butyryl}-methyl-amino)-3-methyl-butyric acid (S)-2-methyl-1-(2-trimethylsilanyl-ethoxycarbonyl)-propyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In dichloromethane; at 0 ℃; for 6h;
DOI:10.1021/jo9616062

Reference yield:

: 17407-55-5
(S)-2-Hydroxy-3-methylbutanoic acid

: 185448-70-8
(S)-2-({(S)-2-[(S)-3-(4-Benzyloxy-phenyl)-2-(tert-butoxycarbonyl-methyl-amino)-propionyloxy]-3-methyl-butyryl}-methyl-amino)-3-methyl-butyric acid (S)-2-methyl-1-(2-trimethylsilanyl-ethoxycarbonyl)-propyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 40 percent / 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride, N,N-dimethyl-4-aminopyridine / pyridine / 36 h / 25 °C

2: 61 percent / diisopropylethylamine, N,N-dimethyl-4-aminopyridine / pyridine / 36 h / 25 °C

3: 100 percent / CF₃COOH / CH₂Cl₂ / 24 h / Ambient temperature

4: 84 percent / bromotris(pyrrolidino)phosphonium hexafluorophosphate, diisopropylethylamine / CH₂Cl₂ / 6 h / 0 °C

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; trifluoroacetic acid; In pyridine; dichloromethane;
DOI:10.1021/jo9616062

Reference yield:

: 185448-87-7
(S)-2-Hydroxy-3-methyl-butyric acid 2-trimethylsilanyl-ethyl ester

: 185448-70-8
(S)-2-({(S)-2-[(S)-3-(4-Benzyloxy-phenyl)-2-(tert-butoxycarbonyl-methyl-amino)-propionyloxy]-3-methyl-butyryl}-methyl-amino)-3-methyl-butyric acid (S)-2-methyl-1-(2-trimethylsilanyl-ethoxycarbonyl)-propyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 61 percent / diisopropylethylamine, N,N-dimethyl-4-aminopyridine / pyridine / 36 h / 25 °C

2: 100 percent / CF₃COOH / CH₂Cl₂ / 24 h / Ambient temperature

3: 84 percent / bromotris(pyrrolidino)phosphonium hexafluorophosphate, diisopropylethylamine / CH₂Cl₂ / 6 h / 0 °C

With dmap; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; trifluoroacetic acid; In pyridine; dichloromethane;
DOI:10.1021/jo9616062