(S)-5-Benzyloxycarbonylamino-2-[(R)-2-({(S)-2-[(S)-2-({(S)-2-[(S)-3-(4-benzyloxy-phenyl)-2-methylamino-propionyloxy]-3-methyl-butyryl}-methyl-amino)-3-methyl-butyryloxy]-3-methyl-butyryl}-methyl-amino)-3-(1H-indol-3-yl)-propionyloxy]-pentanoic acid

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Chemical Name:(S)-5-Benzyloxycarbonylamino-2-[(R)-2-({(S)-2-[(S)-2-({(S)-2-[(S)-3-(4-benzyloxy-phenyl)-2-methylamino-propionyloxy]-3-methyl-butyryl}-methyl-amino)-3-methyl-butyryloxy]-3-methyl-butyryl}-methyl-amino)-3-(1H-indol-3-yl)-propionyloxy]-pentanoic acid
CAS No.:185448-57-1
Molecular Formula:C₅₈H₇₃N₅O₁₃
Molecular Weight:1048.24
Hs Code.:

(S)-5-Benzyloxycarbonylamino-2-[(R)-2-({(S)-2-[(S)-2-({(S)-2-[(S)-3-(4-benzyloxy-phenyl)-2-methylamino-propionyloxy]-3-methyl-butyryl}-methyl-amino)-3-methyl-butyryloxy]-3-methyl-butyryl}-methyl-amino)-3-(1H-indol-3-yl)-propionyloxy]-pentanoic acid

Synonyms:(S)-5-Benzyloxycarbonylamino-2-[(R)-2-({(S)-2-[(S)-2-({(S)-2-[(S)-3-(4-benzyloxy-phenyl)-2-methylamino-propionyloxy]-3-methyl-butyryl}-methyl-amino)-3-methyl-butyryloxy]-3-methyl-butyryl}-methyl-amino)-3-(1H-indol-3-yl)-propionyloxy]-pentanoic acid

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Chemical Property of (S)-5-Benzyloxycarbonylamino-2-[(R)-2-({(S)-2-[(S)-2-({(S)-2-[(S)-3-(4-benzyloxy-phenyl)-2-methylamino-propionyloxy]-3-methyl-butyryl}-methyl-amino)-3-methyl-butyryloxy]-3-methyl-butyryl}-methyl-amino)-3-(1H-indol-3-yl)-propionyloxy]-pentanoic acid

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Technology Process of (S)-5-Benzyloxycarbonylamino-2-[(R)-2-({(S)-2-[(S)-2-({(S)-2-[(S)-3-(4-benzyloxy-phenyl)-2-methylamino-propionyloxy]-3-methyl-butyryl}-methyl-amino)-3-methyl-butyryloxy]-3-methyl-butyryl}-methyl-amino)-3-(1H-indol-3-yl)-propionyloxy]-pentanoic acid

There total 20 articles about (S)-5-Benzyloxycarbonylamino-2-[(R)-2-({(S)-2-[(S)-2-({(S)-2-[(S)-3-(4-benzyloxy-phenyl)-2-methylamino-propionyloxy]-3-methyl-butyryl}-methyl-amino)-3-methyl-butyryloxy]-3-methyl-butyryl}-methyl-amino)-3-(1H-indol-3-yl)-propionyloxy]-pentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 185448-58-2
C₆₃H₈₁N₅O₁₅

: 185448-57-1
(S)-5-Benzyloxycarbonylamino-2-[(R)-2-({(S)-2-[(S)-2-({(S)-2-[(S)-3-(4-benzyloxy-phenyl)-2-methylamino-propionyloxy]-3-methyl-butyryl}-methyl-amino)-3-methyl-butyryloxy]-3-methyl-butyryl}-methyl-amino)-3-(1H-indol-3-yl)-propionyloxy]-pentanoic acid

Guidance literature:: With hydrogenchloride; In ethyl acetate; 1.) -40 deg C, 25 min, 2.) -40 deg C to room temp., 5 min;
DOI:10.1021/jo9616062

Reference yield:

: 17407-55-5
(S)-2-Hydroxy-3-methylbutanoic acid

: 185448-57-1
(S)-5-Benzyloxycarbonylamino-2-[(R)-2-({(S)-2-[(S)-2-({(S)-2-[(S)-3-(4-benzyloxy-phenyl)-2-methylamino-propionyloxy]-3-methyl-butyryl}-methyl-amino)-3-methyl-butyryloxy]-3-methyl-butyryl}-methyl-amino)-3-(1H-indol-3-yl)-propionyloxy]-pentanoic acid

Guidance literature:: Multi-step reaction with 8 steps

1: 40 percent / 1-<3-(dimethylamino)propyl>-3-ethylcarbodiimide hydrochloride, N,N-dimethyl-4-aminopyridine / pyridine / 36 h / 25 °C

2: 61 percent / diisopropylethylamine, N,N-dimethyl-4-aminopyridine / pyridine / 36 h / 25 °C

3: 100 percent / CF₃COOH / CH₂Cl₂ / 24 h / Ambient temperature

4: 84 percent / bromotris(pyrrolidino)phosphonium hexafluorophosphate, diisopropylethylamine / CH₂Cl₂ / 6 h / 0 °C

5: 100 percent / Bu₄NF / tetrahydrofuran / Ambient temperature

6: 26 percent / bromotris(pyrrolidino)phosphonium hexafluorophosphate, diisopropylethylamine / CH₂Cl₂ / 20 h / 0 - 20 °C

7: 100 percent / Bu₄NF / dimethylformamide; tetrahydrofuran / 0.25 h

8: 100 percent / HCl / ethyl acetate / 1.) -40 deg C, 25 min, 2.) -40 deg C to room temp., 5 min

With hydrogenchloride; dmap; tetrabutyl ammonium fluoride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; trifluoroacetic acid; In tetrahydrofuran; pyridine; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jo9616062

Reference yield:

: 185448-87-7
(S)-2-Hydroxy-3-methyl-butyric acid 2-trimethylsilanyl-ethyl ester

: 185448-57-1
(S)-5-Benzyloxycarbonylamino-2-[(R)-2-({(S)-2-[(S)-2-({(S)-2-[(S)-3-(4-benzyloxy-phenyl)-2-methylamino-propionyloxy]-3-methyl-butyryl}-methyl-amino)-3-methyl-butyryloxy]-3-methyl-butyryl}-methyl-amino)-3-(1H-indol-3-yl)-propionyloxy]-pentanoic acid

Guidance literature:: Multi-step reaction with 7 steps

1: 61 percent / diisopropylethylamine, N,N-dimethyl-4-aminopyridine / pyridine / 36 h / 25 °C

2: 100 percent / CF₃COOH / CH₂Cl₂ / 24 h / Ambient temperature

3: 84 percent / bromotris(pyrrolidino)phosphonium hexafluorophosphate, diisopropylethylamine / CH₂Cl₂ / 6 h / 0 °C

4: 100 percent / Bu₄NF / tetrahydrofuran / Ambient temperature

5: 26 percent / bromotris(pyrrolidino)phosphonium hexafluorophosphate, diisopropylethylamine / CH₂Cl₂ / 20 h / 0 - 20 °C

6: 100 percent / Bu₄NF / dimethylformamide; tetrahydrofuran / 0.25 h

7: 100 percent / HCl / ethyl acetate / 1.) -40 deg C, 25 min, 2.) -40 deg C to room temp., 5 min

With hydrogenchloride; dmap; tetrabutyl ammonium fluoride; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; trifluoroacetic acid; In tetrahydrofuran; pyridine; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jo9616062