ethyl 7‐[7,8‐bis(acetyloxy)‐2,3‐bis(4‐methylphenyl)‐5H,6H,7H,8H‐pyrido[2,3‐b]pyrazin‐5‐yl]heptanoate

Base Information

Chemical Name:ethyl 7‐[7,8‐bis(acetyloxy)‐2,3‐bis(4‐methylphenyl)‐5H,6H,7H,8H‐pyrido[2,3‐b]pyrazin‐5‐yl]heptanoate
CAS No.:1356333-01-1
Molecular Formula:C₃₄H₄₁N₃O₆
Molecular Weight:587.716
Hs Code.:

Synonyms:ethyl 7‐[7,8‐bis(acetyloxy)‐2,3‐bis(4‐methylphenyl)‐5H,6H,7H,8H‐pyrido[2,3‐b]pyrazin‐5‐yl]heptanoate

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Chemical Property of ethyl 7‐[7,8‐bis(acetyloxy)‐2,3‐bis(4‐methylphenyl)‐5H,6H,7H,8H‐pyrido[2,3‐b]pyrazin‐5‐yl]heptanoate

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Technology Process of ethyl 7‐[7,8‐bis(acetyloxy)‐2,3‐bis(4‐methylphenyl)‐5H,6H,7H,8H‐pyrido[2,3‐b]pyrazin‐5‐yl]heptanoate

There total 7 articles about ethyl 7‐[7,8‐bis(acetyloxy)‐2,3‐bis(4‐methylphenyl)‐5H,6H,7H,8H‐pyrido[2,3‐b]pyrazin‐5‐yl]heptanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3990-05-4
ethyl 6-formylhexanoate

: 1356333-00-0
7‐(acetyloxy)‐2,3‐bis(4‐methylphenyl)‐5H,6H,7H,8H‐pyrido[2,3‐b]pyrazin‐8‐yl acetate

: 1356333-01-1
ethyl 7‐[7,8‐bis(acetyloxy)‐2,3‐bis(4‐methylphenyl)‐5H,6H,7H,8H‐pyrido[2,3‐b]pyrazin‐5‐yl]heptanoate

Guidance literature:: With sodium tris(acetoxy)borohydride; In 1,2-dichloro-ethane; at 20 ℃; for 66h;

Reference yield:

: 1356332-96-1
2,3-di-p-tolyl-5,6-dihydropyrido[2,3-b]pyrazine

: 1356333-01-1
ethyl 7‐[7,8‐bis(acetyloxy)‐2,3‐bis(4‐methylphenyl)‐5H,6H,7H,8H‐pyrido[2,3‐b]pyrazin‐5‐yl]heptanoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-butyllithium / diethyl ether; hexanes / 0.17 h / -78 °C

1.2: -78 - 20 °C

2.1: sodium hydrogensulfite; potassium permanganate; methyl tributylammonium chloride / dichloromethane; water / 0 - 10 °C / Inert atmosphere

3.1: pyridine / 18 h / 20 °C

4.1: hydrogenchloride / 1,4-dioxane / 0.33 h / 20 °C

5.1: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 66 h / 20 °C

With pyridine; hydrogenchloride; potassium permanganate; n-butyllithium; sodium tris(acetoxy)borohydride; sodium hydrogensulfite; methyl tributylammonium chloride; In 1,4-dioxane; hexanes; diethyl ether; dichloromethane; water; 1,2-dichloro-ethane;

Reference yield:

: 1356332-98-3
7,8-dihydroxy-2,3-di-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-carboxylic acid tert-butyl ester

: 1356333-01-1
ethyl 7‐[7,8‐bis(acetyloxy)‐2,3‐bis(4‐methylphenyl)‐5H,6H,7H,8H‐pyrido[2,3‐b]pyrazin‐5‐yl]heptanoate

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / 18 h / 20 °C

2: hydrogenchloride / 1,4-dioxane / 0.33 h / 20 °C

3: sodium tris(acetoxy)borohydride / 1,2-dichloro-ethane / 66 h / 20 °C

With pyridine; hydrogenchloride; sodium tris(acetoxy)borohydride; In 1,4-dioxane; 1,2-dichloro-ethane;