7‐(acetyloxy)‐2,3‐bis(4‐methylphenyl)‐5H,6H,7H,8H‐pyrido[2,3‐b]pyrazin‐8‐yl acetate

Base Information

Chemical Name:7‐(acetyloxy)‐2,3‐bis(4‐methylphenyl)‐5H,6H,7H,8H‐pyrido[2,3‐b]pyrazin‐8‐yl acetate
CAS No.:1356333-00-0
Molecular Formula:C₂₅H₂₅N₃O₄
Molecular Weight:431.491
Hs Code.:

Synonyms:7‐(acetyloxy)‐2,3‐bis(4‐methylphenyl)‐5H,6H,7H,8H‐pyrido[2,3‐b]pyrazin‐8‐yl acetate

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Chemical Property of 7‐(acetyloxy)‐2,3‐bis(4‐methylphenyl)‐5H,6H,7H,8H‐pyrido[2,3‐b]pyrazin‐8‐yl acetate

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Technology Process of 7‐(acetyloxy)‐2,3‐bis(4‐methylphenyl)‐5H,6H,7H,8H‐pyrido[2,3‐b]pyrazin‐8‐yl acetate

There total 6 articles about 7‐(acetyloxy)‐2,3‐bis(4‐methylphenyl)‐5H,6H,7H,8H‐pyrido[2,3‐b]pyrazin‐8‐yl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1356332-99-4
tert‐butyl 7,8‐bis(acetyloxy)‐2,3‐bis(4‐methylphenyl)‐5H,6H,7H,8H‐pyrido[2,3‐b]pyrazine‐5‐carboxylate

: 1356333-00-0
7‐(acetyloxy)‐2,3‐bis(4‐methylphenyl)‐5H,6H,7H,8H‐pyrido[2,3‐b]pyrazin‐8‐yl acetate

Guidance literature:: tert‐butyl 7,8‐bis(acetyloxy)‐2,3‐bis(4‐methylphenyl)‐5H,6H,7H,8H‐pyrido[2,3‐b]pyrazine‐5‐carboxylate; With hydrogenchloride; In 1,4-dioxane; at 20 ℃; for 0.333333h;

With sodium hydrogencarbonate; In 1,4-dioxane;

Reference yield:

: 1356332-96-1
2,3-di-p-tolyl-5,6-dihydropyrido[2,3-b]pyrazine

: 1356333-00-0
7‐(acetyloxy)‐2,3‐bis(4‐methylphenyl)‐5H,6H,7H,8H‐pyrido[2,3‐b]pyrazin‐8‐yl acetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / diethyl ether; hexanes / 0.17 h / -78 °C

1.2: -78 - 20 °C

2.1: sodium hydrogensulfite; potassium permanganate; methyl tributylammonium chloride / dichloromethane; water / 0 - 10 °C / Inert atmosphere

3.1: pyridine / 18 h / 20 °C

4.1: hydrogenchloride / 1,4-dioxane / 0.33 h / 20 °C

With pyridine; hydrogenchloride; potassium permanganate; n-butyllithium; sodium hydrogensulfite; methyl tributylammonium chloride; In 1,4-dioxane; hexanes; diethyl ether; dichloromethane; water;

Reference yield:

: 1356332-98-3
7,8-dihydroxy-2,3-di-p-tolyl-7,8-dihydropyrido[2,3-b]pyrazin-5(6H)-carboxylic acid tert-butyl ester

: 1356333-00-0
7‐(acetyloxy)‐2,3‐bis(4‐methylphenyl)‐5H,6H,7H,8H‐pyrido[2,3‐b]pyrazin‐8‐yl acetate

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / 18 h / 20 °C

2: hydrogenchloride / 1,4-dioxane / 0.33 h / 20 °C

With pyridine; hydrogenchloride; In 1,4-dioxane;