(2S,3S,4S)-N-benzoyl-2-tert-butoxycarbonyl-3-tert-butoxycarbonylmethyl-4-isopropylidenylpyrrolidine

Base Information

Chemical Name:(2S,3S,4S)-N-benzoyl-2-tert-butoxycarbonyl-3-tert-butoxycarbonylmethyl-4-isopropylidenylpyrrolidine
CAS No.:267244-43-9
Molecular Formula:C₂₅H₃₅NO₅
Molecular Weight:429.557
Hs Code.:

Synonyms:(2S,3S,4S)-N-benzoyl-2-tert-butoxycarbonyl-3-tert-butoxycarbonylmethyl-4-isopropylidenylpyrrolidine

Suppliers and Price of (2S,3S,4S)-N-benzoyl-2-tert-butoxycarbonyl-3-tert-butoxycarbonylmethyl-4-isopropylidenylpyrrolidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S,3S,4S)-N-benzoyl-2-tert-butoxycarbonyl-3-tert-butoxycarbonylmethyl-4-isopropylidenylpyrrolidine

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Technology Process of (2S,3S,4S)-N-benzoyl-2-tert-butoxycarbonyl-3-tert-butoxycarbonylmethyl-4-isopropylidenylpyrrolidine

There total 1 articles about (2S,3S,4S)-N-benzoyl-2-tert-butoxycarbonyl-3-tert-butoxycarbonylmethyl-4-isopropylidenylpyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 98-88-4
benzoyl chloride

: 3-tert-butoxycarbonylmethyl-4-isopropenyl-pyrrolidine-2-carboxylic acid tert-butyl ester

: 267244-43-9
(2S,3S,4S)-N-benzoyl-2-tert-butoxycarbonyl-3-tert-butoxycarbonylmethyl-4-isopropylidenylpyrrolidine

Guidance literature:: With sodium hydroxide;
DOI:10.1016/S0960-894X(99)00690-3

Reference yield: 99.0%

: 267244-43-9
(2S,3S,4S)-N-benzoyl-2-tert-butoxycarbonyl-3-tert-butoxycarbonylmethyl-4-isopropylidenylpyrrolidine

: 267244-44-0
(2S,3S,4S)-acetyl-N-benzoyl-2-tert-butoxycarbonyl-3-tert-butoxycarbonylmethyl-4-pyrrolidine

Guidance literature:: (2S,3S,4S)-N-benzoyl-2-tert-butoxycarbonyl-3-tert-butoxycarbonylmethyl-4-isopropylidenylpyrrolidine; With ozone; In methanol; dichloromethane; at -78 ℃;

With triphenylphosphine; In methanol; dichloromethane; at -78 - 20 ℃;
DOI:10.1016/S0960-894X(99)00690-3

Reference yield:

: 267244-43-9
(2S,3S,4S)-N-benzoyl-2-tert-butoxycarbonyl-3-tert-butoxycarbonylmethyl-4-isopropylidenylpyrrolidine

: 339557-52-7
(2S,3S,4S)-N-benzoyl-2-tert-butoxycarbonyl-3-tert-butoxycarbonylmethyl-4-(quinoxal-2'-yl)pyrrolidine

Guidance literature:: Multi-step reaction with 5 steps

1.1: O₃ / CH₂Cl₂; methanol / 0.75 h / -78 °C

1.2: 99 percent / Ph₃P / CH₂Cl₂; methanol / 1 h / 20 °C

2.1: lithium hexamethyldisilylamide / tetrahydrofuran / 0.42 h / -78 °C

3.1: 115 mg / phenyltrimethylammonium tribromide / tetrahydrofuran / 0.5 h / 0 °C

4.1: NaHCO₃ / ethanol / 7 h / Heating

5.1: 26.0 mg / Pd/C / ethanol / 3 h / Heating

With phenyltrimethylammonium tribromide; sodium hydrogencarbonate; ozone; lithium hexamethyldisilazane; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane;
DOI:10.1021/jo000846l