(E)-N-{4-[3-(3-oxo-1H-pyrrolo[3,4-b]quinolin-2(3H)-yl)prop-1-enyl]phenyl}acetic acid

Base Information

Chemical Name:(E)-N-{4-[3-(3-oxo-1H-pyrrolo[3,4-b]quinolin-2(3H)-yl)prop-1-enyl]phenyl}acetic acid
CAS No.:1370636-14-8
Molecular Formula:C₂₂H₁₈N₂O₃
Molecular Weight:358.397
Hs Code.:

Synonyms:(E)-N-{4-[3-(3-oxo-1H-pyrrolo[3,4-b]quinolin-2(3H)-yl)prop-1-enyl]phenyl}acetic acid

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Chemical Property of (E)-N-{4-[3-(3-oxo-1H-pyrrolo[3,4-b]quinolin-2(3H)-yl)prop-1-enyl]phenyl}acetic acid

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Technology Process of (E)-N-{4-[3-(3-oxo-1H-pyrrolo[3,4-b]quinolin-2(3H)-yl)prop-1-enyl]phenyl}acetic acid

There total 4 articles about (E)-N-{4-[3-(3-oxo-1H-pyrrolo[3,4-b]quinolin-2(3H)-yl)prop-1-enyl]phenyl}acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 440084-40-2
2-allyl-1H-pyrrolo[3,4-b]quinolin-3(2H)-one

: 1878-68-8
2-(4-bromophenyl)-acetic acid

: 1370636-14-8
(E)-N-{4-[3-(3-oxo-1H-pyrrolo[3,4-b]quinolin-2(3H)-yl)prop-1-enyl]phenyl}acetic acid

Guidance literature:: With palladium diacetate; caesium carbonate; triphenylphosphine; In water; N,N-dimethyl-formamide; at 120 ℃; for 16h;
DOI:10.1007/s00044-012-0018-x

Reference yield:

: 552-89-6
2-nitro-benzaldehyde

: 1370636-14-8
(E)-N-{4-[3-(3-oxo-1H-pyrrolo[3,4-b]quinolin-2(3H)-yl)prop-1-enyl]phenyl}acetic acid

Guidance literature:: Multi-step reaction with 4 steps

1: methanol; chloroform / 24 h / 20 °C / Reflux; Molecular sieve

2: sodium sulfide / ethanol / 0.42 h / Reflux

3: toluene-4-sulfonic acid / toluene / 12 h / 20 °C / Reflux; Dean-Stark

4: triphenylphosphine; caesium carbonate; palladium diacetate / N,N-dimethyl-formamide; water / 16 h / 120 °C

With sodium sulfide; palladium diacetate; caesium carbonate; toluene-4-sulfonic acid; triphenylphosphine; In methanol; ethanol; chloroform; water; N,N-dimethyl-formamide; toluene;
DOI:10.1007/s00044-012-0018-x

Reference yield:

: 71907-71-6
1-(dimethoxymethyl)-2-aminobenzene

: 1370636-14-8
(E)-N-{4-[3-(3-oxo-1H-pyrrolo[3,4-b]quinolin-2(3H)-yl)prop-1-enyl]phenyl}acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: toluene-4-sulfonic acid / toluene / 12 h / 20 °C / Reflux; Dean-Stark

2: triphenylphosphine; caesium carbonate; palladium diacetate / N,N-dimethyl-formamide; water / 16 h / 120 °C

With palladium diacetate; caesium carbonate; toluene-4-sulfonic acid; triphenylphosphine; In water; N,N-dimethyl-formamide; toluene;
DOI:10.1007/s00044-012-0018-x