Technology Process of (E)-N-{4-[3-(3-oxo-1H-pyrrolo[3,4-b]quinolin-2(3H)-yl)prop-1-enyl]phenyl}acetic acid
There total 4 articles about (E)-N-{4-[3-(3-oxo-1H-pyrrolo[3,4-b]quinolin-2(3H)-yl)prop-1-enyl]phenyl}acetic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
palladium diacetate; caesium carbonate; triphenylphosphine;
In
water; N,N-dimethyl-formamide;
at 120 ℃;
for 16h;
DOI:10.1007/s00044-012-0018-x
- Guidance literature:
-
Multi-step reaction with 4 steps
1: methanol; chloroform / 24 h / 20 °C / Reflux; Molecular sieve
2: sodium sulfide / ethanol / 0.42 h / Reflux
3: toluene-4-sulfonic acid / toluene / 12 h / 20 °C / Reflux; Dean-Stark
4: triphenylphosphine; caesium carbonate; palladium diacetate / N,N-dimethyl-formamide; water / 16 h / 120 °C
With
sodium sulfide; palladium diacetate; caesium carbonate; toluene-4-sulfonic acid; triphenylphosphine;
In
methanol; ethanol; chloroform; water; N,N-dimethyl-formamide; toluene;
DOI:10.1007/s00044-012-0018-x
- Guidance literature:
-
Multi-step reaction with 2 steps
1: toluene-4-sulfonic acid / toluene / 12 h / 20 °C / Reflux; Dean-Stark
2: triphenylphosphine; caesium carbonate; palladium diacetate / N,N-dimethyl-formamide; water / 16 h / 120 °C
With
palladium diacetate; caesium carbonate; toluene-4-sulfonic acid; triphenylphosphine;
In
water; N,N-dimethyl-formamide; toluene;
DOI:10.1007/s00044-012-0018-x