71907-71-6Relevant academic research and scientific papers
Convergent synthesis of 2-aryl-substituted quinolines by gold-catalyzed cascade reaction
Ueda, Hirofumi,Yamaguchi, Minami,Tokuyama, Hidetoshi
, p. 824 - 829 (2016/07/14)
Gold-catalyzed auto-tandem catalysis has been developed for synthesizing 2-aryl-substituted quinolines. The reaction of an aniline bearing an acetal moiety with an aryl alkyne proceeded via formal [4+2]-cycloaddition, which involved the addition of gold acetylide to an oxonium ion to give amino alkyne intermediate and sequential 6-endo-dig cyclization of amino alkyne intermediate by attacking of nitrogen to alkyne moiety activated by gold catalyst. The cationic gold catalyst promoted two different processes by enhancing the nucleophilicity and electrophilicity of alkyne. This convergent synthetic methodology enabled the synthesis of a variety of 2-aryl-substituted quinolines.
Asymmetric a-hydroxylation of a lactone with vinylogous pyridone by using a guanidine-urea bifunctional organocatalyst: Catalytic enantioselective synthesis of a key intermediate for (20S)-camptothecin analogues
Watanabe, Tatsuya,Odagi, Minami,Furukori, Kota,Nagasawa, Kazuo
, p. 591 - 597 (2014/04/03)
We have developed a catalytic asymmetric synthesis of (S)-4-ethyl-6,6- (ethylenedioxy)-7,8-dihydro-4-hydroxy- 1H-pyrano[3,4-f]indolizine-3,10(4H)dione (5a), a synthetic intermediate for (20S)-camptothecin analogues. A key step in this synthesis is an asym
Synthesis of novel building blocks of 1H-pyrrolo[3,4-b]quinolin-3(2H)-one and evaluation of their antitumor activity
Nagarapua, Lingaiah,Gaikwad, Hanmant K.,Manikonda, Sheeba Rani,Bantu, Rajashaker,Manda, Krishna Madhuri,Kalivendi, Shasi Vardhan
, p. 165 - 174 (2013/03/13)
A series of new building blocks consisting of 1H-pyrrolo[3,4-b]quinolin- 3(2H)-one with potential as selective antitumor agents is described. Compounds were synthesized by using Heck reaction of N-allyl-1H-pyrrolo[3,4-b]quinolin- 3(2H)-one with p-bromophe
An improved synthesis of methyl 1,3-dihydro-2H-pyrrolo[3,4-b]quinoline-2- carboxylate
Akue-Gedu, Rufine,Gautret, Philippe,Lelieur, Jean-Pierre,Rigo, Benoit
, p. 3319 - 3322 (2008/09/20)
Optimization of an old route leads very easily, in four steps, to methyl 1,3-dihydro-2H-pyrrolo[3,4-b]quinoline-2-carboxylate in 45% yield from commercial starting materials. This procedure can be compared to recently described methods whose yields were o
