2-(benzimidazol-2-thio)-N-(2-bromoethyl)-N-(2,4-difluorobenzyl)ethanamine

Base Information

• Chemical Name: 2-(benzimidazol-2-thio)-N-(2-bromoethyl)-N-(2,4-difluorobenzyl)ethanamine
• CAS No.: 1383982-08-8
• Molecular Formula: C₁₈H₁₈BrF₂N₃S
• Molecular Weight: 426.328
• Mol file: 1383982-08-8.mol

Synonyms:2-(benzimidazol-2-thio)-N-(2-bromoethyl)-N-(2,4-difluorobenzyl)ethanamine

Chemical Property of 2-(benzimidazol-2-thio)-N-(2-bromoethyl)-N-(2,4-difluorobenzyl)ethanamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(benzimidazol-2-thio)-N-(2-bromoethyl)-N-(2,4-difluorobenzyl)ethanamine

There total 3 articles about 2-(benzimidazol-2-thio)-N-(2-bromoethyl)-N-(2,4-difluorobenzyl)ethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.1%

2-bromo-N-(2-bromoethyl)-N-(2,4-difluorobenzyl)ethanamine (1096706-55-6) + Benzimidazol-2-thiol (134469-07-1) → 2-(benzimidazol-2-thio)-N-(2-bromoethyl)-N-(2,4-difluorobenzyl)ethanamine (1383982-08-8)

Guidance literature:

Benzimidazol-2-thiol; With potassium carbonate; In acetonitrile; at 60 ℃; for 1h;

2-bromo-N-(2-bromoethyl)-N-(2,4-difluorobenzyl)ethanamine; In acetonitrile; at 20 ℃; for 2h;

DOI:10.1039/c3md00032j

Reference yield:

2,2'-(2,4-difluorobenzylazanediyl)diethanol (416867-47-5) → 2-(benzimidazol-2-thio)-N-(2-bromoethyl)-N-(2,4-difluorobenzyl)ethanamine (1383982-08-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: phosphorus tribromide / chloroform / 2 h / Reflux

2.1: potassium carbonate / acetonitrile / 1 h / 60 °C

2.2: 2 h / 20 °C

With phosphorus tribromide; potassium carbonate; In chloroform; acetonitrile;

DOI:10.1039/c3md00032j

Reference yield:

2,4-difluorobenzyl chloride (452-07-3) → 2-(benzimidazol-2-thio)-N-(2-bromoethyl)-N-(2,4-difluorobenzyl)ethanamine (1383982-08-8)

Guidance literature:

Multi-step reaction with 3 steps

1.1: acetonitrile / 50 °C

2.1: phosphorus tribromide / chloroform / 2 h / Reflux

3.1: potassium carbonate / acetonitrile / 1 h / 60 °C

3.2: 2 h / 20 °C

With phosphorus tribromide; potassium carbonate; In chloroform; acetonitrile;

DOI:10.1039/c3md00032j

upstream raw materials:

2,2'-(2,4-difluorobenzylazanediyl)diethanol

2-bromo-N-(2-bromoethyl)-N-(2,4-difluorobenzyl)ethanamine

Benzimidazol-2-thiol

2,4-difluorobenzyl chloride

Downstream raw materials:

C₃₇H₃₃F₂N₄O₄S⁽¹⁺⁾*Cl^(1-)