452-07-3

Usage

Uses

Used in Pharmaceutical Industry:
2,4-Difluorobenzyl chloride is used as an intermediate for the synthesis of various pharmaceutical compounds. Its ability to introduce fluorine atoms into organic molecules enhances the properties of the resulting pharmaceuticals, such as their bioavailability, metabolic stability, and receptor binding affinity.
Used in Agrochemical Industry:
In the agrochemical industry, 2,4-Difluorobenzyl chloride is utilized as a building block for the development of new agrochemicals. The incorporation of fluorine atoms into these compounds can improve their effectiveness, selectivity, and environmental persistence.
Used in Organic Synthesis:
2,4-Difluorobenzyl chloride is used as a reagent in organic synthesis for the preparation of various fluorinated compounds. Its versatility in chemical reactions allows for the creation of a wide range of organic molecules with potential applications in various fields.
Used in Fluorination Reactions:
As a valuable compound for introducing fluorine atoms into organic molecules, 2,4-Difluorobenzyl chloride is employed in fluorination reactions. This process can significantly alter the properties of the target molecules, leading to improved performance in various applications, such as drug development and material science.

InChI:InChI=1/C7H5ClF2/c8-4-5-1-2-6(9)3-7(5)10/h1-3H,4H2

Upstream product

• 367-29-3 3-fluoro-6-methylaniline 
• 50-00-0 formaldehyd 
• 372-18-9 1,3-Difluorobenzene 

Downstream Products

• 656-35-9 (2,4-difluorophenyl)acetonitrile 
• 132666-62-7 2-[2-(2,4-Difluoro-phenyl)-ethyl]-1H-imidazole 
• 380423-91-6 1-(2,4-difluoro-benzyl)-piperidine-4-carboxylic acid amide 
• 259816-71-2 1-(2,4-difluoro-benzyl)-4-pyridin-4-yl-1H-pyrrole-3-carboxylic acid ethyl ester 
• 405274-90-0 1-(2,4-difluorobenzyl)-3-formyl-1H-indole 
• 558469-88-8 1-(2,4-difluorobenzyl)-3-hydroxymethyl-1H-indole 
• 405275-58-3 1-(2,4-difluorobenzyl)-3-(1-hydroxyethyl)-1H-indole 
• 2647-30-5 2,4-Difluor-α-cyan-stilben 
• 1525-45-7 2,4-Difluor-4'-dimethylamino-α-cyan-stilben 
• 966-98-3 <2,4-Difluor-phenyl>-<4'-dimethylamino-phenyl>-α-cyan-azomethin 
• 225666-55-7 5,6-bis(4-methoxyphenyl)-2-(2,4-difluorobenzyl)-2H-pyridazin-3-one 
• 586379-70-6 methyl 3-(4-(2,4-difluorobenzyloxy)-3-bromo-6-methyl-2-oxopyridin-1(2H)-yl)-4-methylbenzoate 
• 1419175-07-7 2,4-difluoro-1-(2-methyleneoctyl)benzene 
• 622372-75-2 1-(azidomethyl)-2,4-difluorobenzene 

Relevant academic research and scientific papers

2. 4 - difluorobenzene methylamine synthetic method

The invention relates to the fields of medicine and agrochemicals, and concretely relates to a synthetic method of an intermediate 2,4-difluorobenzene methylamine. The synthetic method comprises the following steps: 1) m-difluorobenzene, a halogenating agent and paraformaldehyde are reacted under effect of a catalyst to prepare 2,4-difluoro benzyl halide; 2)the prepared 2,4-difluoro benzyl halide and urotropine are reacted to prepare a quaternary ammonium salt compound IV; 3)the prepared quaternary ammonium salt compound is hydrolyzed by concentrated hydrochloric acid to obtain 2,4-difluorobenzene methylamine. The method has the advantages of low cost of the prepared 2,4-difluorobenzene methylamine, convenient operation and high security coefficient, and is suitable for industrial production.

[4,5]-fused-3,6-disubstituted-pyridazines with sulfur-containing substituents in position three for the treatment of neoplasia

[4,5]-Fused-3,6 disubstituted-pydidazines of Formula I are useful for inducing or promoting apoptosis and for arresting uncontrolled neoplastic cell proliferation, and are specifically useful in the arresting and treatment of neoplasia: wherein Y1and Y2are independently selected from the group consisting of (CH2)n,—C(X)—NH—,—(CH2)n—C(X)—O—, and X is O or S; R1is selected from the group consisting of lower alkyl, lower alkenyl, lower alkynyl, and substituted or unsubstituted phenyl, pyridinyl, and the like; R2is selected from the group consisting of substituted or unsubstituted phenyl, benzyl, pyridinyl, and the like; “A” is a benzene ring fused with the pyridazine ring; and R3is independently selected in each instance form the group consisting of halogen, lower alkyl, and the like.