(S)-2-Pent-4-enoylamino-succinic acid 1-cyanomethyl ester 4-(4,5-dimethoxy-2-nitro-benzyl) ester

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Chemical Name:(S)-2-Pent-4-enoylamino-succinic acid 1-cyanomethyl ester 4-(4,5-dimethoxy-2-nitro-benzyl) ester
CAS No.:201869-62-7
Molecular Formula:C₂₀H₂₃N₃O₉
Molecular Weight:449.417
Hs Code.:

Synonyms:(S)-2-Pent-4-enoylamino-succinic acid 1-cyanomethyl ester 4-(4,5-dimethoxy-2-nitro-benzyl) ester

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Chemical Property of (S)-2-Pent-4-enoylamino-succinic acid 1-cyanomethyl ester 4-(4,5-dimethoxy-2-nitro-benzyl) ester

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Technology Process of (S)-2-Pent-4-enoylamino-succinic acid 1-cyanomethyl ester 4-(4,5-dimethoxy-2-nitro-benzyl) ester

There total 5 articles about (S)-2-Pent-4-enoylamino-succinic acid 1-cyanomethyl ester 4-(4,5-dimethoxy-2-nitro-benzyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 107-14-2
chloroacetonitrile

: (S)-2-Pent-4-enoylamino-succinic acid 4-(4,5-dimethoxy-2-nitro-benzyl) ester

: 201869-62-7
(S)-2-Pent-4-enoylamino-succinic acid 1-cyanomethyl ester 4-(4,5-dimethoxy-2-nitro-benzyl) ester

Guidance literature:: With triethylamine; In acetonitrile; for 6h; Ambient temperature;
DOI:10.1021/jo971692l

Reference yield:

: 591-80-0
pent-4-enoic acid

: 201869-62-7
(S)-2-Pent-4-enoylamino-succinic acid 1-cyanomethyl ester 4-(4,5-dimethoxy-2-nitro-benzyl) ester

Guidance literature:: Multi-step reaction with 5 steps

1: 89 percent / N-methylmorpholine, hydroxybenzotriazole, N,N'-dicyclohexylcarbodiimide / CH₂Cl₂ / 18 h / Ambient temperature

2: aq. NaOH / tetrahydrofuran / 3 h / Ambient temperature

3: CsF / dimethylformamide / 6 h / Ambient temperature

4: LiOH / tetrahydrofuran; H₂O / 4 h

5: 46 percent / Et₃N / acetonitrile / 6 h / Ambient temperature

With 4-methyl-morpholine; lithium hydroxide; sodium hydroxide; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; cesium fluoride; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jo971692l

Reference yield:

: (S)-2-Pent-4-enoylamino-succinic acid

: 201869-62-7
(S)-2-Pent-4-enoylamino-succinic acid 1-cyanomethyl ester 4-(4,5-dimethoxy-2-nitro-benzyl) ester

Guidance literature:: Multi-step reaction with 3 steps

1: CsF / dimethylformamide / 6 h / Ambient temperature

2: LiOH / tetrahydrofuran; H₂O / 4 h

3: 46 percent / Et₃N / acetonitrile / 6 h / Ambient temperature

With lithium hydroxide; triethylamine; cesium fluoride; In tetrahydrofuran; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jo971692l