1-(3-methoxyphenyl)-5-methyl-1H-1,2,3-triazole-4-carboxylic acid

Base Information

• Chemical Name: 1-(3-methoxyphenyl)-5-methyl-1H-1,2,3-triazole-4-carboxylic acid
• CAS No.: 386264-51-3
• Molecular Formula: C₁₁H₁₁N₃O₃
• Molecular Weight: 233.227
• Mol file: 386264-51-3.mol

Synonyms:5-methyl-1-[3-(methyloxy)phenyl]-1H-1,2,3-triazole-4-carboxylic acid

Chemical Property of 1-(3-methoxyphenyl)-5-methyl-1H-1,2,3-triazole-4-carboxylic acid

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

1-(3-Methoxy-phenyl)-5-methyl-1H-[1,2,3]triazole-4-carboxylic acid ^*data from reagent suppliers

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Technology Process of 1-(3-methoxyphenyl)-5-methyl-1H-1,2,3-triazole-4-carboxylic acid

There total 4 articles about 1-(3-methoxyphenyl)-5-methyl-1H-1,2,3-triazole-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

3-methoxyphenyl azide (3866-16-8) + ethyl acetoacetate (141-97-9) → 5-methyl-1-[3-(methyloxy)phenyl]-1H-1,2,3-triazole-4-carboxylic acid (386264-51-3)

Guidance literature:

With sodium methylate; In methanol;

DOI:10.1134/S1070428008100217

Reference yield:

m-Anisidine (536-90-3,918666-97-4) → 5-methyl-1-[3-(methyloxy)phenyl]-1H-1,2,3-triazole-4-carboxylic acid (386264-51-3)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium nitrite; hydrogenchloride / water

2: Alkaline conditions

3: sodium hydroxide

With hydrogenchloride; sodium hydroxide; sodium nitrite; In water;

DOI:10.1016/j.molstruc.2021.131146

Reference yield:

C13H15N3O3 (1362020-64-1) → 5-methyl-1-[3-(methyloxy)phenyl]-1H-1,2,3-triazole-4-carboxylic acid (386264-51-3)

Guidance literature:

With sodium hydroxide;

DOI:10.1016/j.molstruc.2021.131146

upstream raw materials:

3-methoxyphenyl azide

ethyl acetoacetate

C₁₃H₁₅N₃O₃

m-Anisidine

Downstream raw materials:

C₁₁H₁₀ClN₃O₂

5-methyl-1-[3-(methyloxy)phenyl]-N-(6-methyl-2-pyridinyl)-1H-1,2,3-triazole-4-carboxamide

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