3866-16-8

Basic information

• Product Name: 3-Azidoanisole
• Synonyms: 1-Azido-3-methoxybenzene;3-Azidoanisole;3-Methoxyphenyl azide;1-Azido-3-methoxybenzene solution;3-Azidoanisole solution;3-Methoxyphenyl azide solution
• CAS NO: 3866-16-8
• Molecular Formula: C₇H₇N₃O
• Molecular Weight: 0
• Product Categories: Aromatic Azides;Azides;Building Blocks;Chemical Synthesis;Nitrogen Compounds;Organic Building Blocks
• Mol File: 3866-16-8.mol
• Article Data: 85

Chemical Properties

• Flash Point: -33°C
• Appearance: /
• Storage Temp.: ?20°C
• BRN: 2090296
• CAS DataBase Reference: 3-Azidoanisole(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Azidoanisole(3866-16-8)
• EPA Substance Registry System: 3-Azidoanisole(3866-16-8)

Safety Data

• Hazard Codes: F,T
• Statements: 11-38-48/23/24/25
• Safety Statements: 16
• RIDADR: UN 2398 3 / PGII
• WGK Germany: 3
• Hazardous Substances Data: 3866-16-8(Hazardous Substances Data)

Upstream product

• 536-90-3 m-Anisidine 
• 15384-39-1 (3-methoxyphenyl)hydrazine 
• 2398-37-0 3-methoxyphenyl bromide 
• 2845-89-8 1-chloro-3-methoxy-benzene 
• 766-85-8 3-methoxy-1-iodobenzene 
• 19183-05-2 3-methoxy-benzenediazonium; chloride 
• 10365-98-7 3-methoxyphenylboronic acid 
• 555-03-3 3-nitroanisole 

Downstream Products

• 536-90-3 m-Anisidine 
• 386264-51-3 5-methyl-1-[3-(methyloxy)phenyl]-1H-1,2,3-triazole-4-carboxylic acid 
• 108429-57-8 1-(m-methoxyphenyl)-1H-1,2,3-triazole 
• 1259900-48-5 1-(3-methoxyphenyl)-4-phenyl-1H-1,2,3-triazole 
• 101078-45-9 N-(3-methoxyphenyl)-4-methyl-benzamide 

Relevant articles and documents

Towards smart biocide-free anti-biofilm strategies: Click-based synthesis of cinnamide analogues as anti-biofilm compounds against marine bacteria

A set of triazole-based analogues of N-coumaroyltyramine was designed to discover potential leads that may help in the control of bacterial biofilms. the most potent compounds act as inhibitors of biofilm development with EC50 closed to ampicillin (EC50 =

[HDBU][HSO4]-catalyzed facile synthesis of new 1,2,3-triazole-tethered 2,3-dihydroquinazolin-4[1H]-one derivatives and their DPPH radical scavenging activity

A simple and efficient protocol has been developed for the synthesis of new1,2,3-triazole-2,3-dihydroquinazolin-4[1H]-one (DHQ) conjugates(6a?j) via ultrasound-assisted, solvent-free ionic liquid [HDBU][HSO4]-catalyzed reaction in good to excellent yields. This non-conventional, ultrasound-assisted route has taken the reactions over the conventional reflux method to provide good to excellent yields of the corresponding products (6a?j) in a very short time. In addition, mild reaction conditions, tolerance to functionalized substrates, ease of product isolation, prevention of its over oxidation and reusability of catalyst [HDBU][HSO4] are some key striking features of the methodology. The newly synthesized derivatives (6a?j) were screened for antioxidant activity using 1,1-diphenyl-2-picryl hydrazyl (DPPH) assay and are found to be a potent scavenger. The compounds 6b, 6c, 6d, 6e and 6i showed significant antioxidant activity. Molecular docking studies showed significant binding affinity in the active site of myeloperoxidase (MPO) enzyme and hence scavenged by inhibition of MPO. In silico ADMET and pharmacokinetic studies of the conjugates are very promising; a cumulative body of evidence suggests their medicinal value as a potential orally active drug candidate. Graphical abstract: [Figure not available: see fulltext.]

Discovery of new tranylcypromine derivatives as highly potent LSD1 inhibitors

Tranylcypromine (TCP)-based structural modifications lead to the discovery of new LSD1 inhibitors, of which compounds 26b and 29b effectively inhibit LSD1 with the IC50 values of 17 and 11 nM, respectively and also show good selectivity over MAO-B. Mechanistic studies showed that compound 29b concentration-dependently induced H3K4me1/2 accumulation in LSD1 overexpressed MGC-803 cells and also inhibited metastasis of MGC-803 cells. Collectively, both compounds could be promising lead compounds for further investigation.