methyl 5-[(tert-butoxycarbonyl)amino]-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}valerate

Base Information

Chemical Name:methyl 5-[(tert-butoxycarbonyl)amino]-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}valerate
CAS No.:1335144-15-4
Molecular Formula:C₂₂H₃₇N₃O₄
Molecular Weight:407.553
Hs Code.:

Synonyms:methyl 5-[(tert-butoxycarbonyl)amino]-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}valerate

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Chemical Property of methyl 5-[(tert-butoxycarbonyl)amino]-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}valerate

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Technology Process of methyl 5-[(tert-butoxycarbonyl)amino]-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}valerate

There total 8 articles about methyl 5-[(tert-butoxycarbonyl)amino]-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}valerate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₂H₃₅N₃O₄

: 1335144-15-4
methyl 5-[(tert-butoxycarbonyl)amino]-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}valerate

Guidance literature:: With palladium 10% on activated carbon; water; hydrogen; In ethanol; at 20 - 60 ℃; for 6.5h; under 760.051 Torr;

Reference yield:

: 1335139-07-5
dimethyl 2-(3-((tert-butoxycarbonyl)amino)propyl)malonate

: 1335144-15-4
methyl 5-[(tert-butoxycarbonyl)amino]-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}valerate

Guidance literature:: Multi-step reaction with 3 steps

1: lithium hydroxide monohydrate / methanol; water / 15 h / 0 - 20 °C

2: piperidine; propionic acid / cyclohexane / 48 h / Reflux

3: palladium 10% on activated carbon; hydrogen; water / ethanol / 6.5 h / 20 - 60 °C / 760.05 Torr

With piperidine; lithium hydroxide monohydrate; palladium 10% on activated carbon; water; hydrogen; propionic acid; In methanol; ethanol; cyclohexane; water; 2: |Knoevenagel Condensation;

Reference yield:

: 1335139-06-4
5-[(tert-butoxycarbonyl)amino]-2-(methoxycarbonyl)valeric acid

: 1335144-15-4
methyl 5-[(tert-butoxycarbonyl)amino]-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}valerate

Guidance literature:: Multi-step reaction with 2 steps

1: piperidine; propionic acid / cyclohexane / 48 h / Reflux

2: palladium 10% on activated carbon; hydrogen; water / ethanol / 6.5 h / 20 - 60 °C / 760.05 Torr

With piperidine; palladium 10% on activated carbon; water; hydrogen; propionic acid; In ethanol; cyclohexane; 1: |Knoevenagel Condensation;