(2S)-5-amino-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}valeric acid

Base Information

Chemical Name:(2S)-5-amino-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}valeric acid
CAS No.:1335138-62-9
Molecular Formula:C₁₆H₂₇N₃O₂
Molecular Weight:293.409
Hs Code.:

Synonyms:(2S)-5-amino-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}valeric acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S)-5-amino-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}valeric acid

Chemical Property:

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Technology Process of (2S)-5-amino-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}valeric acid

There total 9 articles about (2S)-5-amino-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}valeric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1335139-72-4
methyl (2S)-5-[(tert-butoxycarbonyl)amino]-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}valerate

: 1335138-62-9
(2S)-5-amino-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}valeric acid

Guidance literature:: With hydrogenchloride; water; for 4h; Reflux;

Reference yield:

: 1335139-07-5
dimethyl 2-(3-((tert-butoxycarbonyl)amino)propyl)malonate

: 1335138-62-9
(2S)-5-amino-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}valeric acid

Guidance literature:: Multi-step reaction with 5 steps

1: lithium hydroxide monohydrate / methanol; water / 15 h / 0 - 20 °C

2: piperidine; propionic acid / cyclohexane / 48 h / Reflux

3: palladium 10% on activated carbon; hydrogen; water / ethanol / 6.5 h / 20 - 60 °C / 760.05 Torr

4: CHIRALPAK IA / ethanol; hexane / Resolution of racemate

5: water; hydrogenchloride / 4 h / Reflux

With piperidine; hydrogenchloride; lithium hydroxide monohydrate; palladium 10% on activated carbon; water; hydrogen; propionic acid; In methanol; ethanol; hexane; cyclohexane; water; 2: |Knoevenagel Condensation;

Reference yield:

: 1335139-06-4
5-[(tert-butoxycarbonyl)amino]-2-(methoxycarbonyl)valeric acid

: 1335138-62-9
(2S)-5-amino-2-{[1-(trans-4-methylcyclohexyl)-1H-imidazol-4-yl]methyl}valeric acid

Guidance literature:: Multi-step reaction with 4 steps

1: piperidine; propionic acid / cyclohexane / 48 h / Reflux

2: palladium 10% on activated carbon; hydrogen; water / ethanol / 6.5 h / 20 - 60 °C / 760.05 Torr

3: CHIRALPAK IA / ethanol; hexane / Resolution of racemate

4: water; hydrogenchloride / 4 h / Reflux

With piperidine; hydrogenchloride; palladium 10% on activated carbon; water; hydrogen; propionic acid; In ethanol; hexane; cyclohexane; 1: |Knoevenagel Condensation;