2,4-dimethyl-5-methylene-3-phenyl-4-phenylsulphonylisoxazolidine

Base Information

• Chemical Name: 2,4-dimethyl-5-methylene-3-phenyl-4-phenylsulphonylisoxazolidine
• CAS No.: 107403-03-2
• Molecular Formula: C₁₈H₁₉NO₃S
• Molecular Weight: 329.42
• Mol file: 107403-03-2.mol

Synonyms:2,4-dimethyl-5-methylene-3-phenyl-4-phenylsulphonylisoxazolidine

Chemical Property of 2,4-dimethyl-5-methylene-3-phenyl-4-phenylsulphonylisoxazolidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,4-dimethyl-5-methylene-3-phenyl-4-phenylsulphonylisoxazolidine

There total 3 articles about 2,4-dimethyl-5-methylene-3-phenyl-4-phenylsulphonylisoxazolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(benzylidene)methylamine N-oxide (3376-23-6,7372-59-0,59862-60-1) → 2,4-dimethyl-5-methylene-3-phenyl-4-phenylsulphonylisoxazolidine (107403-03-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / benzene / 6 h / 40 °C

2: 1.)LDA

With lithium diisopropyl amide; In benzene;

DOI:10.1016/S0040-4039(00)84616-X

Reference yield:

phenylsulfonylpropa-1,2-diene (2525-42-0) → 2,4-dimethyl-5-methylene-3-phenyl-4-phenylsulphonylisoxazolidine (107403-03-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / benzene / 6 h / 40 °C

2: 1.)LDA

With lithium diisopropyl amide; In benzene;

DOI:10.1016/S0040-4039(00)84616-X

Reference yield:

2-methyl-3-phenyl-4-(phenylsulfonyl)-5-methyleneisoxazolidine (107402-95-9) + methyl iodide (74-88-4) → 2,4-dimethyl-5-methylene-3-phenyl-4-phenylsulphonylisoxazolidine (107403-03-2)

Guidance literature:

With n-butyllithium; diisopropylamine; Yield given. Multistep reaction; 1.) THF, -78 deg C, 45 min, 2.) 0 deg C, 1 h;

DOI:10.1039/P19880002639

upstream raw materials:

2-methyl-3-phenyl-4-(phenylsulfonyl)-5-methyleneisoxazolidine

methyl iodide

N-(benzylidene)methylamine N-oxide

phenylsulfonylpropa-1,2-diene

Downstream raw materials:

5-methoxy-2,4,5-trimethyl-3-phenyl-4-phenylsulphonylisoxazolidine

3-(phenylsulfonyl)butan-2-one

N-Benzylidenemethylamine