4-[3-(3,5-dichloro-2,4-difluorophenyl)-3-(trifluoromethyl)pyrrolidin-1-yl]-2-(trifluoromethyl)benzonitrile

Base Information

Chemical Name:4-[3-(3,5-dichloro-2,4-difluorophenyl)-3-(trifluoromethyl)pyrrolidin-1-yl]-2-(trifluoromethyl)benzonitrile
CAS No.:1364674-16-7
Molecular Formula:C₁₉H₁₀Cl₂F₈N₂
Molecular Weight:489.195
Hs Code.:

Synonyms:4-[3-(3,5-dichloro-2,4-difluorophenyl)-3-(trifluoromethyl)pyrrolidin-1-yl]-2-(trifluoromethyl)benzonitrile

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Chemical Property of 4-[3-(3,5-dichloro-2,4-difluorophenyl)-3-(trifluoromethyl)pyrrolidin-1-yl]-2-(trifluoromethyl)benzonitrile

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Technology Process of 4-[3-(3,5-dichloro-2,4-difluorophenyl)-3-(trifluoromethyl)pyrrolidin-1-yl]-2-(trifluoromethyl)benzonitrile

There total 5 articles about 4-[3-(3,5-dichloro-2,4-difluorophenyl)-3-(trifluoromethyl)pyrrolidin-1-yl]-2-(trifluoromethyl)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1364674-15-6
3-(3,5-dichloro-2,4-difluorophenyl)-3-(trifluoromethyl)pyrrolidine

: 194853-86-6
4-fluoro-2-(trifluoromethyl)benzonitrile

: 1364674-16-7
4-[3-(3,5-dichloro-2,4-difluorophenyl)-3-(trifluoromethyl)pyrrolidin-1-yl]-2-(trifluoromethyl)benzonitrile

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In ISOPROPYLAMIDE; at 20 ℃; for 1h; microwave reactor;

Reference yield:

: 83121-15-7
3,5-dichloro-2,4-difluoro-aniline

: 1364674-16-7
4-[3-(3,5-dichloro-2,4-difluorophenyl)-3-(trifluoromethyl)pyrrolidin-1-yl]-2-(trifluoromethyl)benzonitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: copper(l) iodide; hydrogen iodide / water / 30 °C

1.2: 30 °C

2.1: potassium carbonate / bis-triphenylphosphine-palladium(II) chloride / water; tetrahydrofuran / 3 h / Inert atmosphere; Reflux

3.1: trifluoroacetic acid / dichloromethane / 20 °C / Cooling with ice

4.1: isopropyl chloroformate / 1,2-dichloro-ethane / 3 h / 20 °C / Reflux

4.2: 2 h / Reflux

5.1: N-ethyl-N,N-diisopropylamine / ISOPROPYLAMIDE / 1 h / 20 °C / microwave reactor

With copper(l) iodide; hydrogen iodide; potassium carbonate; isopropyl chloroformate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; dichloromethane; ISOPROPYLAMIDE; water; 1,2-dichloro-ethane;

Reference yield:

: 1364674-12-3
1,3-dichloro-2,4-difluoro-5-iodobenzene

: 1364674-16-7
4-[3-(3,5-dichloro-2,4-difluorophenyl)-3-(trifluoromethyl)pyrrolidin-1-yl]-2-(trifluoromethyl)benzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / bis-triphenylphosphine-palladium(II) chloride / water; tetrahydrofuran / 3 h / Inert atmosphere; Reflux

2.1: trifluoroacetic acid / dichloromethane / 20 °C / Cooling with ice

3.1: isopropyl chloroformate / 1,2-dichloro-ethane / 3 h / 20 °C / Reflux

3.2: 2 h / Reflux

4.1: N-ethyl-N,N-diisopropylamine / ISOPROPYLAMIDE / 1 h / 20 °C / microwave reactor

With potassium carbonate; isopropyl chloroformate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; bis-triphenylphosphine-palladium(II) chloride; In tetrahydrofuran; dichloromethane; ISOPROPYLAMIDE; water; 1,2-dichloro-ethane;