allyl (2S)-2-[(benzyloxy)carbonyl]amino-3-[((2S)-2-[(tert-butoxycarbonyl)amino]-8-hydroxy-1,2,3,4-tetrahydro-2-naphthalenylcarbonyl)(methyl)amino]propanoate

Base Information

Chemical Name:allyl (2S)-2-[(benzyloxy)carbonyl]amino-3-[((2S)-2-[(tert-butoxycarbonyl)amino]-8-hydroxy-1,2,3,4-tetrahydro-2-naphthalenylcarbonyl)(methyl)amino]propanoate
CAS No.:1264240-64-3
Molecular Formula:C₃₁H₃₉N₃O₈
Molecular Weight:581.666
Hs Code.:

allyl (2S)-2-[(benzyloxy)carbonyl]amino-3-[((2S)-2-[(tert-butoxycarbonyl)amino]-8-hydroxy-1,2,3,4-tetrahydro-2-naphthalenylcarbonyl)(methyl)amino]propanoate

Synonyms:allyl (2S)-2-[(benzyloxy)carbonyl]amino-3-[((2S)-2-[(tert-butoxycarbonyl)amino]-8-hydroxy-1,2,3,4-tetrahydro-2-naphthalenylcarbonyl)(methyl)amino]propanoate

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Chemical Property of allyl (2S)-2-[(benzyloxy)carbonyl]amino-3-[((2S)-2-[(tert-butoxycarbonyl)amino]-8-hydroxy-1,2,3,4-tetrahydro-2-naphthalenylcarbonyl)(methyl)amino]propanoate

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Technology Process of allyl (2S)-2-[(benzyloxy)carbonyl]amino-3-[((2S)-2-[(tert-butoxycarbonyl)amino]-8-hydroxy-1,2,3,4-tetrahydro-2-naphthalenylcarbonyl)(methyl)amino]propanoate

There total 4 articles about allyl (2S)-2-[(benzyloxy)carbonyl]amino-3-[((2S)-2-[(tert-butoxycarbonyl)amino]-8-hydroxy-1,2,3,4-tetrahydro-2-naphthalenylcarbonyl)(methyl)amino]propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 1264239-65-7
(S)-allyl 2-(benzyloxycarbonylamino)-3-(methylamino)propanoate hydrochloride

: 168629-12-7
(S)-2-<(tert-butoxy)carbonylamino>-8-hydroxy-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid

: 1264240-64-3
allyl (2S)-2-[(benzyloxy)carbonyl]amino-3-[((2S)-2-[(tert-butoxycarbonyl)amino]-8-hydroxy-1,2,3,4-tetrahydro-2-naphthalenylcarbonyl)(methyl)amino]propanoate

Guidance literature:: With 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 72h;

Reference yield:

: Z-Dap(Me)-OH hydrochloride

: 1264240-64-3
allyl (2S)-2-[(benzyloxy)carbonyl]amino-3-[((2S)-2-[(tert-butoxycarbonyl)amino]-8-hydroxy-1,2,3,4-tetrahydro-2-naphthalenylcarbonyl)(methyl)amino]propanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: thionyl chloride / 1.75 h / 20 - 70 °C

1.2: 0.08 h

2.1: 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 72 h / 20 °C

With thionyl chloride; 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide;

Reference yield:

: 1145-80-8
N-(benzyloxycarbonyl)-L-serine

: 1264240-64-3
allyl (2S)-2-[(benzyloxy)carbonyl]amino-3-[((2S)-2-[(tert-butoxycarbonyl)amino]-8-hydroxy-1,2,3,4-tetrahydro-2-naphthalenylcarbonyl)(methyl)amino]propanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: triphenylphosphine; diethylazodicarboxylate

2.1: thionyl chloride / 1.75 h / 20 - 70 °C

2.2: 0.08 h

3.1: 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 72 h / 20 °C

With thionyl chloride; 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; diethylazodicarboxylate; In N,N-dimethyl-formamide;