(2R,4aR,6R,8aS)-2-(4-Octyloxy-phenylethynyl)-6-(4-tetradecyloxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxine

Base Information

Chemical Name:(2R,4aR,6R,8aS)-2-(4-Octyloxy-phenylethynyl)-6-(4-tetradecyloxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxine
CAS No.:178267-52-2
Molecular Formula:C₄₃H₆₄O₅
Molecular Weight:660.978
Hs Code.:

Synonyms:(2R,4aR,6R,8aS)-2-(4-Octyloxy-phenylethynyl)-6-(4-tetradecyloxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxine

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Chemical Property of (2R,4aR,6R,8aS)-2-(4-Octyloxy-phenylethynyl)-6-(4-tetradecyloxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxine

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Technology Process of (2R,4aR,6R,8aS)-2-(4-Octyloxy-phenylethynyl)-6-(4-tetradecyloxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxine

There total 8 articles about (2R,4aR,6R,8aS)-2-(4-Octyloxy-phenylethynyl)-6-(4-tetradecyloxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: (2R,3S,6R)-2-Hydroxymethyl-6-(4-tetradecyloxy-phenyl)-tetrahydro-pyran-3-ol

: 1-(4-octyloxyphenyl)prop-1-ynal dimethyl acetal

: 178267-52-2
(2R,4aR,6R,8aS)-2-(4-Octyloxy-phenylethynyl)-6-(4-tetradecyloxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxine

Guidance literature:: With toluene-4-sulfonic acid; In N,N-dimethyl-formamide; at 60 ℃; for 1h; under 21.8 - 24.8 Torr;
DOI:10.1039/jm9960600739

Reference yield:

: 35021-69-3
tetradecyl phenyl ether

: 178267-52-2
(2R,4aR,6R,8aS)-2-(4-Octyloxy-phenylethynyl)-6-(4-tetradecyloxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxine

Guidance literature:: Multi-step reaction with 4 steps

1: SnCl₄ / CH₂Cl₂ / Ambient temperature

2: H₂ / 10percent Pd/C / ethanol; ethyl acetate / Ambient temperature

3: NaOMe / methanol / Ambient temperature

4: 57 percent / TsOH*H₂O / dimethylformamide / 1 h / 60 °C / 21.8 - 24.8 Torr

With hydrogen; sodium methylate; tin(IV) chloride; toluene-4-sulfonic acid; palladium on activated charcoal; In methanol; ethanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1039/jm9960600739

Reference yield:

: Acetic acid (2R,3S)-2-acetoxymethyl-6-(4-tetradecyloxy-phenyl)-3,6-dihydro-2H-pyran-3-yl ester

: 178267-52-2
(2R,4aR,6R,8aS)-2-(4-Octyloxy-phenylethynyl)-6-(4-tetradecyloxy-phenyl)-hexahydro-pyrano[3,2-d][1,3]dioxine

Guidance literature:: Multi-step reaction with 3 steps

1: H₂ / 10percent Pd/C / ethanol; ethyl acetate / Ambient temperature

2: NaOMe / methanol / Ambient temperature

3: 57 percent / TsOH*H₂O / dimethylformamide / 1 h / 60 °C / 21.8 - 24.8 Torr

With hydrogen; sodium methylate; toluene-4-sulfonic acid; palladium on activated charcoal; In methanol; ethanol; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1039/jm9960600739