{4-[(E)-3-(4-Hydroxy-phenyl)-3-oxo-propenyl]-2-methoxy-phenoxy}-acetic acid

Base Information

• Chemical Name: {4-[(E)-3-(4-Hydroxy-phenyl)-3-oxo-propenyl]-2-methoxy-phenoxy}-acetic acid
• CAS No.: 909569-68-2
• Molecular Formula: C₁₈H₁₆O₆
• Molecular Weight: 328.321

Synonyms:{4-[(E)-3-(4-Hydroxy-phenyl)-3-oxo-propenyl]-2-methoxy-phenoxy}-acetic acid

Chemical Property of {4-[(E)-3-(4-Hydroxy-phenyl)-3-oxo-propenyl]-2-methoxy-phenoxy}-acetic acid

Chemical Property:

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Technology Process of {4-[(E)-3-(4-Hydroxy-phenyl)-3-oxo-propenyl]-2-methoxy-phenoxy}-acetic acid

There total 2 articles about {4-[(E)-3-(4-Hydroxy-phenyl)-3-oxo-propenyl]-2-methoxy-phenoxy}-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.75%

(4-formyl-2-methoxyphenoxy)acetic acid (1660-19-1) + 4-Hydroxyacetophenone (99-93-4) → {4-[(E)-3-(4-Hydroxy-phenyl)-3-oxo-propenyl]-2-methoxy-phenoxy}-acetic acid (909569-68-2)

Guidance literature:

(4-formyl-2-methoxyphenoxy)acetic acid; 4-Hydroxyacetophenone; With sodium hydroxide; In ethanol; water; for 48h;

With hydrogenchloride; In ethanol; water;

DOI:10.1111/j.1747-0285.2012.01319.x

Reference yield:

vanillin (121-33-5,8014-42-4) → {4-[(E)-3-(4-Hydroxy-phenyl)-3-oxo-propenyl]-2-methoxy-phenoxy}-acetic acid (909569-68-2)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / water / 5 h / Reflux

2: sodium hydroxide / ethanol; water / 48 h

With sodium hydroxide; In ethanol; water; 2: Claisen Schmidt condensation;

DOI:10.1111/j.1747-0285.2012.01319.x

Reference yield: 90.0%

{4-[(E)-3-(4-Hydroxy-phenyl)-3-oxo-propenyl]-2-methoxy-phenoxy}-acetic acid (909569-68-2) + 1-(2-naphthyloxyacetyl)hydrazine (36304-47-9) → (4-{5-(4-hydroxy-phenyl)-1-[(naphthalen-2-yloxy)-acetyl]-4,5-dihydro-1H-pyrazol-3-yl}-2-methoxy-phenoxy)-acetic acid

Guidance literature:

In ethanol; acetic acid; for 4h; Heating;

DOI:10.1016/j.bmcl.2006.06.021

upstream raw materials:

(4-formyl-2-methoxyphenoxy)acetic acid

4-Hydroxyacetophenone

vanillin

Downstream raw materials:

2-(4-(2-amino-6-(4-hydroxyphenyl)pyrimidin-4-yl)-2-methoxyphenoxy)acetic acid

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