(rac)-{[3-{[4-(2,4-difluorophenyl)-5-fluoropyrimidin-2-yl]amino}-5-(trifluoromethyl)benzyl](2-methoxyethyl)oxido-λ⁶-sulfanylidene}cyanamide

Base Information

• Chemical Name: (rac)-{[3-{[4-(2,4-difluorophenyl)-5-fluoropyrimidin-2-yl]amino}-5-(trifluoromethyl)benzyl](2-methoxyethyl)oxido-λ⁶-sulfanylidene}cyanamide
• CAS No.: 1610545-93-1
• Molecular Formula: C₂₂H₁₇F₆N₅O₂S
• Molecular Weight: 529.466

Synonyms:(rac)-{[3-{[4-(2,4-difluorophenyl)-5-fluoropyrimidin-2-yl]amino}-5-(trifluoromethyl)benzyl](2-methoxyethyl)oxido-λ⁶-sulfanylidene}cyanamide

Chemical Property of (rac)-{[3-{[4-(2,4-difluorophenyl)-5-fluoropyrimidin-2-yl]amino}-5-(trifluoromethyl)benzyl](2-methoxyethyl)oxido-λ⁶-sulfanylidene}cyanamide

Chemical Property:

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Technology Process of (rac)-{[3-{[4-(2,4-difluorophenyl)-5-fluoropyrimidin-2-yl]amino}-5-(trifluoromethyl)benzyl](2-methoxyethyl)oxido-λ⁶-sulfanylidene}cyanamide

There total 7 articles about (rac)-{[3-{[4-(2,4-difluorophenyl)-5-fluoropyrimidin-2-yl]amino}-5-(trifluoromethyl)benzyl](2-methoxyethyl)oxido-λ⁶-sulfanylidene}cyanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(rac)-{[3-{[4-(2,4-difluorophenyl)-5-fluoropyrimidin-2-yl]amino}-5-(trifluoromethyl)benzyl](2-methoxyethyl)-λ4-sulfanylidene}cyanamide (1610546-27-4) → (rac)-{[3-{[4-(2,4-difluorophenyl)-5-fluoropyrimidin-2-yl]amino}-5-(trifluoromethyl)benzyl](2-methoxyethyl)oxido-λ6-sulfanylidene}cyanamide (1610545-93-1)

Guidance literature:

With potassium permanganate; In acetone; at 40 ℃; for 0.5h;

Reference yield:

4-(2,4-difluorophenyl)-5-fluoro-N-{3-[((2-methoxyethyl)sulfanyl)methyl]-5-(trifluoromethyl)phenyl}pyrimidin-2-amine (1610546-26-3) → (rac)-{[3-{[4-(2,4-difluorophenyl)-5-fluoropyrimidin-2-yl]amino}-5-(trifluoromethyl)benzyl](2-methoxyethyl)oxido-λ6-sulfanylidene}cyanamide (1610545-93-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione / methanol / 1 h / 0 °C

2: potassium permanganate / acetone / 0.5 h / 40 °C

With potassium permanganate; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; In methanol; acetone;

Reference yield:

2-chloro-4-(2,4-difluorophenyl)-5-fluoropyrimidine (1402545-53-2) → (rac)-{[3-{[4-(2,4-difluorophenyl)-5-fluoropyrimidin-2-yl]amino}-5-(trifluoromethyl)benzyl](2-methoxyethyl)oxido-λ6-sulfanylidene}cyanamide (1610545-93-1)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogenchloride / 1,4-dioxane; butan-1-ol / 20 h / 140 °C

2: 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione / methanol / 1 h / 0 °C

3: potassium permanganate / acetone / 0.5 h / 40 °C

With hydrogenchloride; potassium permanganate; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; In 1,4-dioxane; methanol; acetone; butan-1-ol;

upstream raw materials:

2,4-difluorophenylboronic acid

2-chloro-4-(2,4-difluorophenyl)-5-fluoropyrimidine

tert-butyl-{3-[((2-methoxyethyl)sulfanyl)methyl]-5-(trifluoromethyl)phenyl}carbamate

3-[((2-methoxyethyl)sulfanyl)methyl]-5-(trifluoromethyl)aniline

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