1-{2-[(4-bromophenyl)difluoromethyl]-4,5-dimethylphenyl}prop-2-yn-1-ol

Base Information

Chemical Name:1-{2-[(4-bromophenyl)difluoromethyl]-4,5-dimethylphenyl}prop-2-yn-1-ol
CAS No.:1311146-51-6
Molecular Formula:C₁₈H₁₅BrF₂O
Molecular Weight:365.217
Hs Code.:

Synonyms:1-{2-[(4-bromophenyl)difluoromethyl]-4,5-dimethylphenyl}prop-2-yn-1-ol

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Chemical Property of 1-{2-[(4-bromophenyl)difluoromethyl]-4,5-dimethylphenyl}prop-2-yn-1-ol

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Technology Process of 1-{2-[(4-bromophenyl)difluoromethyl]-4,5-dimethylphenyl}prop-2-yn-1-ol

There total 3 articles about 1-{2-[(4-bromophenyl)difluoromethyl]-4,5-dimethylphenyl}prop-2-yn-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1311146-49-2
2-[(4-bromophenyl)difluoromethyl]-4,5-dimethylbenzaldehyde

: 4301-14-8
acetylenemagnesium bromide

: 1311146-51-6
1-{2-[(4-bromophenyl)difluoromethyl]-4,5-dimethylphenyl}prop-2-yn-1-ol

Guidance literature:: 2-[(4-bromophenyl)difluoromethyl]-4,5-dimethylbenzaldehyde; acetylenemagnesium bromide; In tetrahydrofuran; at 0 ℃; for 3h; Inert atmosphere;

With ammonium chloride; In tetrahydrofuran;
DOI:10.1016/j.tet.2011.03.073

Reference yield:

: 1311146-46-9
{2-[(4-bromophenyl)difluoromethyl]-4,5-dimethylphenyl}methanol

: 1311146-51-6
1-{2-[(4-bromophenyl)difluoromethyl]-4,5-dimethylphenyl}prop-2-yn-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / tetrahydrofuran; dimethyl sulfoxide / 1 h / 40 °C

2: tetrahydrofuran / 3 h / 0 °C / Inert atmosphere

With 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; dimethyl sulfoxide; 2: Grignard reaction;
DOI:10.1016/j.tet.2011.03.073

Reference yield:

: 1311146-41-4
2-[(4-bromophenyl)difluoromethyl]-4,5-dimethylbenzoic acid ethyl ester

: 1311146-51-6
1-{2-[(4-bromophenyl)difluoromethyl]-4,5-dimethylphenyl}prop-2-yn-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1: lithium triethylborohydride / tetrahydrofuran / 0.5 h / 0 - 20 °C / Inert atmosphere

2: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / tetrahydrofuran; dimethyl sulfoxide / 1 h / 40 °C

3: tetrahydrofuran / 3 h / 0 °C / Inert atmosphere

With lithium triethylborohydride; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione; In tetrahydrofuran; dimethyl sulfoxide; 3: Grignard reaction;
DOI:10.1016/j.tet.2011.03.073