1-(3-bromo-4-hydroxyphenyl)-6-chloro-7,8-dihydroxy-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide

Base Information

Chemical Name:1-(3-bromo-4-hydroxyphenyl)-6-chloro-7,8-dihydroxy-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide
CAS No.:80751-91-3
Molecular Formula:BrH*C₁₆H₁₅BrClNO₃
Molecular Weight:465.569
Hs Code.:

Synonyms:1-(3-bromo-4-hydroxyphenyl)-6-chloro-7,8-dihydroxy-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide

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Chemical Property of 1-(3-bromo-4-hydroxyphenyl)-6-chloro-7,8-dihydroxy-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide

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Technology Process of 1-(3-bromo-4-hydroxyphenyl)-6-chloro-7,8-dihydroxy-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide

There total 8 articles about 1-(3-bromo-4-hydroxyphenyl)-6-chloro-7,8-dihydroxy-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 789437-49-6
3-Allyl-6-chloro-1-(4-chloro-3-methoxy-phenyl)-7,8-dimethoxy-2,3,4,5-tetrahydro-1H-benzo[d]azepine

: 80751-91-3
1-(3-bromo-4-hydroxyphenyl)-6-chloro-7,8-dihydroxy-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide

Guidance literature:: With boron tribromide; In dichloromethane; at 25 ℃; for 18h;
DOI:10.1021/jm00346a005

Reference yield:

: 13726-16-4
4-chloro-3-methoxybenzaldehyde

: 80751-91-3
1-(3-bromo-4-hydroxyphenyl)-6-chloro-7,8-dihydroxy-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) 50percent NaH suspension in mineral oil, Me₂SO / 1.) THF, 0 deg C, 5 min, 2.) a) 0 deg C, 15 min, b) 25 deg C, 2h

2: 18 h / 110 °C

3: H₂SO₄, CF₃COOH / 2 h / Heating

4: K₂CO₃ / dimethylformamide / 2 h / 120 °C

5: 67 percent / BBr₃ / CH₂Cl₂ / 18 h / 25 °C

With sulfuric acid; boron tribromide; sodium hydride; potassium carbonate; dimethyl sulfoxide; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00346a005

Reference yield:

: 13726-17-5
(4-chloro-3-methoxyphenyl)methan-1-ol

: 80751-91-3
1-(3-bromo-4-hydroxyphenyl)-6-chloro-7,8-dihydroxy-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide

Guidance literature:: Multi-step reaction with 6 steps

1: MnO₂ / toluene / 80 °C

2: 1.) 50percent NaH suspension in mineral oil, Me₂SO / 1.) THF, 0 deg C, 5 min, 2.) a) 0 deg C, 15 min, b) 25 deg C, 2h

3: 18 h / 110 °C

4: H₂SO₄, CF₃COOH / 2 h / Heating

5: K₂CO₃ / dimethylformamide / 2 h / 120 °C

6: 67 percent / BBr₃ / CH₂Cl₂ / 18 h / 25 °C

With manganese(IV) oxide; sulfuric acid; boron tribromide; sodium hydride; potassium carbonate; dimethyl sulfoxide; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00346a005