3-Allyl-6-chloro-1-(4-chloro-3-methoxy-phenyl)-7,8-dimethoxy-2,3,4,5-tetrahydro-1H-benzo[d]azepine

Base Information

Chemical Name:3-Allyl-6-chloro-1-(4-chloro-3-methoxy-phenyl)-7,8-dimethoxy-2,3,4,5-tetrahydro-1H-benzo[d]azepine
CAS No.:789437-49-6
Molecular Formula:C₂₂H₂₅Cl₂NO₃
Molecular Weight:422.351
Hs Code.:

Synonyms:3-Allyl-6-chloro-1-(4-chloro-3-methoxy-phenyl)-7,8-dimethoxy-2,3,4,5-tetrahydro-1H-benzo[d]azepine

Suppliers and Price of 3-Allyl-6-chloro-1-(4-chloro-3-methoxy-phenyl)-7,8-dimethoxy-2,3,4,5-tetrahydro-1H-benzo[d]azepine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-Allyl-6-chloro-1-(4-chloro-3-methoxy-phenyl)-7,8-dimethoxy-2,3,4,5-tetrahydro-1H-benzo[d]azepine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-Allyl-6-chloro-1-(4-chloro-3-methoxy-phenyl)-7,8-dimethoxy-2,3,4,5-tetrahydro-1H-benzo[d]azepine

There total 7 articles about 3-Allyl-6-chloro-1-(4-chloro-3-methoxy-phenyl)-7,8-dimethoxy-2,3,4,5-tetrahydro-1H-benzo[d]azepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 345319-56-4
6-Chloro-1-(4-chloro-3-methoxy-phenyl)-7,8-dimethoxy-2,3,4,5-tetrahydro-1H-benzo[d]azepine

: 106-95-6
allyl bromide

: 789437-49-6
3-Allyl-6-chloro-1-(4-chloro-3-methoxy-phenyl)-7,8-dimethoxy-2,3,4,5-tetrahydro-1H-benzo[d]azepine

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 120 ℃; for 2h;
DOI:10.1021/jm00346a005

Reference yield:

: 13726-16-4
4-chloro-3-methoxybenzaldehyde

: 789437-49-6
3-Allyl-6-chloro-1-(4-chloro-3-methoxy-phenyl)-7,8-dimethoxy-2,3,4,5-tetrahydro-1H-benzo[d]azepine

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) 50percent NaH suspension in mineral oil, Me₂SO / 1.) THF, 0 deg C, 5 min, 2.) a) 0 deg C, 15 min, b) 25 deg C, 2h

2: 18 h / 110 °C

3: H₂SO₄, CF₃COOH / 2 h / Heating

4: K₂CO₃ / dimethylformamide / 2 h / 120 °C

With sulfuric acid; sodium hydride; potassium carbonate; dimethyl sulfoxide; trifluoroacetic acid; In N,N-dimethyl-formamide;
DOI:10.1021/jm00346a005

Reference yield:

: 13726-17-5
(4-chloro-3-methoxyphenyl)methan-1-ol

: 789437-49-6
3-Allyl-6-chloro-1-(4-chloro-3-methoxy-phenyl)-7,8-dimethoxy-2,3,4,5-tetrahydro-1H-benzo[d]azepine

Guidance literature:: Multi-step reaction with 5 steps

1: MnO₂ / toluene / 80 °C

2: 1.) 50percent NaH suspension in mineral oil, Me₂SO / 1.) THF, 0 deg C, 5 min, 2.) a) 0 deg C, 15 min, b) 25 deg C, 2h

3: 18 h / 110 °C

4: H₂SO₄, CF₃COOH / 2 h / Heating

5: K₂CO₃ / dimethylformamide / 2 h / 120 °C

With manganese(IV) oxide; sulfuric acid; sodium hydride; potassium carbonate; dimethyl sulfoxide; trifluoroacetic acid; In N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00346a005