Technology Process of 2,6-difluoro-N-[3-(3-{2-[(3-morpholin-4-ylphenyl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]benzamide
There total 11 articles about 2,6-difluoro-N-[3-(3-{2-[(3-morpholin-4-ylphenyl)amino]pyrimidin-4-yl}imidazo[1,2-a]pyridin-2-yl)phenyl]benzamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
C27H25N7O; 2,6-difluorobenzoylchloride;
In
tetrahydrofuran;
at 20 ℃;
for 16h;
With
sodium carbonate;
In
tetrahydrofuran; water; ethyl acetate;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: sodium hydrogencarbonate / ethanol / 4 h / 20 °C
2.1: N-iodo-succinimide / N,N-dimethyl-formamide / 4 h / 20 °C
3.1: bis-triphenylphosphine-palladium(II) chloride / toluene / 27 h / 110 °C
3.2: 16 h / 20 °C
4.1: 1-methyl-pyrrolidin-2-one / 1.5 h / 90 °C
5.1: potassium carbonate / 1-methyl-pyrrolidin-2-one / 82 h / 90 °C
6.1: water; ammonium chloride; iron / ethanol / 2.5 h / 90 °C
7.1: tetrahydrofuran / 16 h / 20 °C
With
N-iodo-succinimide; water; iron; sodium hydrogencarbonate; potassium carbonate; ammonium chloride;
bis-triphenylphosphine-palladium(II) chloride;
In
tetrahydrofuran; 1-methyl-pyrrolidin-2-one; ethanol; N,N-dimethyl-formamide; toluene;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: N-iodo-succinimide / N,N-dimethyl-formamide / 4 h / 20 °C
2.1: bis-triphenylphosphine-palladium(II) chloride / toluene / 27 h / 110 °C
2.2: 16 h / 20 °C
3.1: 1-methyl-pyrrolidin-2-one / 1.5 h / 90 °C
4.1: potassium carbonate / 1-methyl-pyrrolidin-2-one / 82 h / 90 °C
5.1: water; ammonium chloride; iron / ethanol / 2.5 h / 90 °C
6.1: tetrahydrofuran / 16 h / 20 °C
With
N-iodo-succinimide; water; iron; potassium carbonate; ammonium chloride;
bis-triphenylphosphine-palladium(II) chloride;
In
tetrahydrofuran; 1-methyl-pyrrolidin-2-one; ethanol; N,N-dimethyl-formamide; toluene;
