Bis(4-hydroxyphenyl)phenylmethane

Base Information

• Chemical Name: Bis(4-hydroxyphenyl)phenylmethane
• CAS No.: 4081-02-1
• Molecular Formula: C19H16O2
• Molecular Weight: 276.335
• Hs Code.: 2907299090
• DSSTox Substance ID: DTXSID80401859
• Nikkaji Number: J519.679E
• Wikidata: Q82205124
• Mol file: 4081-02-1.mol

Synonyms:4081-02-1;4,4'-(phenylmethylene)diphenol;4,4'-dihydroxytriphenylmethane;bis(4-hydroxyphenyl)phenylmethane;4-[(4-hydroxyphenyl)-phenylmethyl]phenol;Dioxytriphenylmethan;4,4'-Benzylidenebisphenol;SCHEMBL36791;CBDivE_002802;DTXSID80401859;RSSGMIIGVQRGDS-UHFFFAOYSA-N;bis(4-hydroxyphenyl)-phenylmethane;CS-D0501;MFCD00411649;AKOS024279991;4-[(4-hydroxyphenyl)(phenyl)methyl]phenol;F51065;SR-01000390236;SR-01000390236-1

Chemical Property of Bis(4-hydroxyphenyl)phenylmethane

Chemical Property:

• PSA: 40.46000
• LogP: 4.27800
• XLogP3: 4.3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 276.115029749
• Heavy Atom Count: 21
• Complexity: 273

Purity/Quality:

99% ^*data from raw suppliers

4,4'-(Phenylmethylene)diphenol 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C(C2=CC=C(C=C2)O)C3=CC=C(C=C3)O

Technology Process of Bis(4-hydroxyphenyl)phenylmethane

There total 15 articles about Bis(4-hydroxyphenyl)phenylmethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

phenyl N-tosyl imine (51608-60-7) + phenol (108-95-2,27073-41-2) → 4,4'-benzylidene-di-phenol (4081-02-1)

Guidance literature:

With chloro-trimethyl-silane; bismuth(III) sulfate; In dichloromethane; at 20 ℃; for 1h;

DOI:10.1039/b800066b

Reference yield: 75.0%

benzaldehyde (100-52-7) + phenol (108-95-2,27073-41-2) → 4,4'-benzylidene-di-phenol (4081-02-1)

Guidance literature:

With chloro-trimethyl-silane; bismuth(III) sulfate; at 20 ℃; for 1h;

DOI:10.1002/cjoc.201300522

Reference yield: 69.1%

4-(3,5-dibromo-4-hydroxy-α-phenylbenzylidene)-2,6-dibromo-2,5-cyclohexadien-1-one sodium salt → 4,4'-benzylidene-di-phenol (4081-02-1)

Guidance literature:

With hydrogen; sodium acetate; palladium on activated charcoal; In methanol; for 7h; Ambient temperature;

DOI:10.1246/bcsj.66.337

upstream raw materials:

Hydroxy-phenyl-bis-(4-hydroxy-phenyl)-methan

phenolphthalin

4,4'-benzylidenedianiline

benzaldehyde

Downstream raw materials:

4,4'-(phenylmethylene)bis(4,1-phenylene) diacetate

Hydroxy-phenyl-bis-(4-hydroxy-phenyl)-methan

4,4'-benzylidene-bis-cyclohexanol

p-benzylphenol