N-(5-Amino-6-methoxy-tetrahydro-pyran-2-ylmethyl)-2,2,2-trifluoro-N-(1-phenyl-ethyl)-acetamide

Base Information

Chemical Name:N-(5-Amino-6-methoxy-tetrahydro-pyran-2-ylmethyl)-2,2,2-trifluoro-N-(1-phenyl-ethyl)-acetamide
CAS No.:91704-27-7
Molecular Formula:C₁₇H₂₃F₃N₂O₃
Molecular Weight:360.376
Hs Code.:

Synonyms:N-(5-Amino-6-methoxy-tetrahydro-pyran-2-ylmethyl)-2,2,2-trifluoro-N-(1-phenyl-ethyl)-acetamide

Suppliers and Price of N-(5-Amino-6-methoxy-tetrahydro-pyran-2-ylmethyl)-2,2,2-trifluoro-N-(1-phenyl-ethyl)-acetamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(5-Amino-6-methoxy-tetrahydro-pyran-2-ylmethyl)-2,2,2-trifluoro-N-(1-phenyl-ethyl)-acetamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of N-(5-Amino-6-methoxy-tetrahydro-pyran-2-ylmethyl)-2,2,2-trifluoro-N-(1-phenyl-ethyl)-acetamide

There total 12 articles about N-(5-Amino-6-methoxy-tetrahydro-pyran-2-ylmethyl)-2,2,2-trifluoro-N-(1-phenyl-ethyl)-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 91704-26-6
2,2,2-Trifluoro-N-(5-hydroxyamino-6-methoxy-tetrahydro-pyran-2-ylmethyl)-N-(1-phenyl-ethyl)-acetamide

: 91704-27-7
N-(5-Amino-6-methoxy-tetrahydro-pyran-2-ylmethyl)-2,2,2-trifluoro-N-(1-phenyl-ethyl)-acetamide

Guidance literature:: With hydrogen; palladium on activated charcoal; In acetic acid; for 48h; under 760 Torr; Yield given; Ambient temperature;
DOI:10.1016/S0040-4039(01)90091-7

Reference yield:

: 91704-26-6
2,2,2-Trifluoro-N-((2S,5R,6S)-5-hydroxyamino-6-methoxy-tetrahydro-pyran-2-ylmethyl)-N-((R)-1-phenyl-ethyl)-acetamide

: 91704-27-7
N-((2S,5R,6S)-5-Amino-6-methoxy-tetrahydro-pyran-2-ylmethyl)-2,2,2-trifluoro-N-((R)-1-phenyl-ethyl)-acetamide

Guidance literature:: With hydrogen; palladium on activated charcoal; In acetic acid; for 3h; under 750.06 Torr; Ambient temperature;

Reference yield:

: 3886-69-9
(R)-1-phenyl-ethyl-amine

: 91704-27-7
N-(5-Amino-6-methoxy-tetrahydro-pyran-2-ylmethyl)-2,2,2-trifluoro-N-(1-phenyl-ethyl)-acetamide

Guidance literature:: Multi-step reaction with 7 steps

1: 0 °C

2: NaBH₄ / ethanol / 0 °C

3: pyridine / CH₂Cl₂ / 0 °C

4: NOCl / CH₂Cl₂ / 0.08 h / -70 °C

5: 94 percent / HCl-buffer, 1,3,5-trimethyl-pyrazole / dimethylformamide

6: NaBH₃CN / acetic acid / 25 °C

7: H₂ / Pd/C / acetic acid / 48 h / 760 Torr / Ambient temperature

With pyridine; 1,3,5-trimethyl-1H-pyrazole; sodium tetrahydroborate; HCl-buffer; hydrogen; sodium cyanoborohydride; nitrosylchloride; palladium on activated charcoal; In ethanol; dichloromethane; acetic acid; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(01)90091-7