(2S)-2-[N-trifluoroacetyl-N-((R)-phenylethyl)aminomethyl]-3,4-dihydro-2H-pyran

Base Information

Chemical Name:(2S)-2-[N-trifluoroacetyl-N-((R)-phenylethyl)aminomethyl]-3,4-dihydro-2H-pyran
CAS No.:91704-05-1
Molecular Formula:C₁₆H₁₈F₃NO₂
Molecular Weight:313.32
Hs Code.:

Synonyms:(2S)-2-[N-trifluoroacetyl-N-((R)-phenylethyl)aminomethyl]-3,4-dihydro-2H-pyran

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (2S)-2-[N-trifluoroacetyl-N-((R)-phenylethyl)aminomethyl]-3,4-dihydro-2H-pyran

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Technology Process of (2S)-2-[N-trifluoroacetyl-N-((R)-phenylethyl)aminomethyl]-3,4-dihydro-2H-pyran

There total 5 articles about (2S)-2-[N-trifluoroacetyl-N-((R)-phenylethyl)aminomethyl]-3,4-dihydro-2H-pyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 2-<(1R)-phenylethylaminomethyl>-3,4-dihydro-2H-pyran

: 407-25-0
trifluoroacetic anhydride

: 91704-05-1
(2S)-2-[N-trifluoroacetyl-N-((R)-phenylethyl)aminomethyl]-3,4-dihydro-2H-pyran

: (2R)-2-aminomethyl>-3,4-dihydro-2H-pyran

Guidance literature:: In pyridine; at 0 ℃; for 1h;

Reference yield:

: 91704-02-8,91704-03-9
(3,4-Dihydro-2H-pyran-2-ylmethyl)-((R)-1-phenyl-ethyl)-amine

: 407-25-0
trifluoroacetic anhydride

: 91704-05-1
N-(3,4-Dihydro-2H-pyran-2-ylmethyl)-2,2,2-trifluoro-N-((R)-1-phenyl-ethyl)-acetamide

Guidance literature:: With pyridine; In dichloromethane; at 0 ℃;
DOI:10.1016/S0040-4039(01)90091-7

Reference yield:

: 100-73-2
acrolein dimer

: 91704-05-1
N-(3,4-Dihydro-2H-pyran-2-ylmethyl)-2,2,2-trifluoro-N-((R)-1-phenyl-ethyl)-acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: 0 °C

2: NaBH₄ / ethanol / 0 °C

3: pyridine / CH₂Cl₂ / 0 °C

With pyridine; sodium tetrahydroborate; In ethanol; dichloromethane;
DOI:10.1016/S0040-4039(01)90091-7