5-(2-fluoro-3-methoxyphenyl)-N-(3-hydroxybenzyl)-N-methylthiophene-2-sulfonamide

Base Information

Chemical Name:5-(2-fluoro-3-methoxyphenyl)-N-(3-hydroxybenzyl)-N-methylthiophene-2-sulfonamide
CAS No.:1396243-71-2
Molecular Formula:C₁₉H₁₈FNO₄S₂
Molecular Weight:407.487
Hs Code.:

Synonyms:5-(2-fluoro-3-methoxyphenyl)-N-(3-hydroxybenzyl)-N-methylthiophene-2-sulfonamide

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Chemical Property of 5-(2-fluoro-3-methoxyphenyl)-N-(3-hydroxybenzyl)-N-methylthiophene-2-sulfonamide

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Technology Process of 5-(2-fluoro-3-methoxyphenyl)-N-(3-hydroxybenzyl)-N-methylthiophene-2-sulfonamide

There total 3 articles about 5-(2-fluoro-3-methoxyphenyl)-N-(3-hydroxybenzyl)-N-methylthiophene-2-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 19.0%

: 1282488-31-6
5-bromo-N-(3-hydroxybenzyl)-N-methylthiophene-2-sulfonamide

: 352303-67-4
(2-fluoro-3-methoxyphenyl)boronic acid

: 1396243-71-2
5-(2-fluoro-3-methoxyphenyl)-N-(3-hydroxybenzyl)-N-methylthiophene-2-sulfonamide

Guidance literature:: With caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; ethanol; water; at 150 ℃; for 0.25h; under 3750.38 Torr; Inert atmosphere; microwave irradiation;

Reference yield:

: 41789-95-1
1-(3-methoxyphenyl)-N-methylmethanamine

: 1396243-71-2
5-(2-fluoro-3-methoxyphenyl)-N-(3-hydroxybenzyl)-N-methylthiophene-2-sulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide; tetra(n-butyl)ammonium hydrogensulfate / dichloromethane / 5 h / 20 °C

2: boron dimethyl-trifluoro sulphide / dichloromethane / 0 - 20 °C

3: caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; ethanol; water / 0.33 h / 150 °C / Sealed tube; Inert atmosphere; Microwave irradiation

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; boron dimethyl-trifluoro sulphide; tetra(n-butyl)ammonium hydrogensulfate; caesium carbonate; sodium hydroxide; In 1,2-dimethoxyethane; ethanol; dichloromethane; water; 3: |Suzuki-Miyaura Coupling;
DOI:10.1016/j.ejmech.2014.06.036

Reference yield:

: 1276378-65-4
5-bromo-N-(3-methoxybenzyl)-N-methylthiophene-2-sulfonamide

: 1396243-71-2
5-(2-fluoro-3-methoxyphenyl)-N-(3-hydroxybenzyl)-N-methylthiophene-2-sulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: boron dimethyl-trifluoro sulphide / dichloromethane / 0 - 20 °C

2: caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; ethanol; water / 0.33 h / 150 °C / Sealed tube; Inert atmosphere; Microwave irradiation

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; boron dimethyl-trifluoro sulphide; caesium carbonate; In 1,2-dimethoxyethane; ethanol; dichloromethane; water; 2: |Suzuki-Miyaura Coupling;
DOI:10.1016/j.ejmech.2014.06.036