ethyl-2-(3-phenyl-2,4-dioxo-3,4-dihydroquinazolin-1(2H)-yl)acetate

Base Information

• Chemical Name: ethyl-2-(3-phenyl-2,4-dioxo-3,4-dihydroquinazolin-1(2H)-yl)acetate
• CAS No.: 128650-95-3
• Molecular Formula: C₁₈H₁₆N₂O₄
• Molecular Weight: 324.336
• Mol file: 128650-95-3.mol

Synonyms:ethyl-2-(3-phenyl-2,4-dioxo-3,4-dihydroquinazolin-1(2H)-yl)acetate

Chemical Property of ethyl-2-(3-phenyl-2,4-dioxo-3,4-dihydroquinazolin-1(2H)-yl)acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl-2-(3-phenyl-2,4-dioxo-3,4-dihydroquinazolin-1(2H)-yl)acetate

There total 8 articles about ethyl-2-(3-phenyl-2,4-dioxo-3,4-dihydroquinazolin-1(2H)-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

3-phenyl-2,4-(1H,3H)-quinazolinedione (603-23-6) + chloroacetic acid ethyl ester (105-39-5) → ethyl-2-(3-phenyl-2,4-dioxo-3,4-dihydroquinazolin-1(2H)-yl)acetate (128650-95-3)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 90 ℃; for 6h; chemoselective reaction;

DOI:10.3998/ark.5550190.0018.400

Reference yield:

N-(3,4-Dihydro-4-oxo-3-phenylquinazolin-2-ylmercaptoacetyl)hydrazine (37029-30-4) → ethyl-2-(3-phenyl-2,4-dioxo-3,4-dihydroquinazolin-1(2H)-yl)acetate (128650-95-3)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium nitrite; hydrogenchloride; acetic acid / water / 24 h / -5 - 25 °C

2: sodium hydride / mineral oil; N,N-dimethyl-formamide / 6 h / 90 °C

With hydrogenchloride; sodium hydride; acetic acid; sodium nitrite; In water; N,N-dimethyl-formamide; mineral oil;

DOI:10.3998/ark.5550190.0018.400

Reference yield:

anthranilic acid (118-92-3,159201-01-1,50816-84-7,80206-34-4,104809-47-4) → ethyl-2-(3-phenyl-2,4-dioxo-3,4-dihydroquinazolin-1(2H)-yl)acetate (128650-95-3)

Guidance literature:

Multi-step reaction with 3 steps

1: acetonitrile / 4 h / 80 °C

2: sodium hydroxide / ethanol / 4 h / 80 °C

3: sodium hydride / mineral oil; N,N-dimethyl-formamide / 6 h / 90 °C

With sodium hydride; sodium hydroxide; In ethanol; N,N-dimethyl-formamide; acetonitrile; mineral oil;

DOI:10.3998/ark.5550190.0018.400

upstream raw materials:

3-phenyl-2,4-(1H,3H)-quinazolinedione

ethyl bromoacetate

N-(3,4-Dihydro-4-oxo-3-phenylquinazolin-2-ylmercaptoacetyl)hydrazine

anthranilic acid