(S)-3-aminomethyl-N₆-(5-cyclopropyl-1H-pyrazol-3-yl)-5-fluoro-N₂-[1-(4-fluorophenyl)ethyl]pyridine-2,6-diamine

Base Information

• Chemical Name: (S)-3-aminomethyl-N₆-(5-cyclopropyl-1H-pyrazol-3-yl)-5-fluoro-N₂-[1-(4-fluorophenyl)ethyl]pyridine-2,6-diamine
• CAS No.: 905585-65-1
• Molecular Formula: C₂₀H₂₂F₂N₆
• Molecular Weight: 384.432

Synonyms:(S)-3-aminomethyl-N₆-(5-cyclopropyl-1H-pyrazol-3-yl)-5-fluoro-N₂-[1-(4-fluorophenyl)ethyl]pyridine-2,6-diamine

Chemical Property of (S)-3-aminomethyl-N₆-(5-cyclopropyl-1H-pyrazol-3-yl)-5-fluoro-N₂-[1-(4-fluorophenyl)ethyl]pyridine-2,6-diamine

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Technology Process of (S)-3-aminomethyl-N₆-(5-cyclopropyl-1H-pyrazol-3-yl)-5-fluoro-N₂-[1-(4-fluorophenyl)ethyl]pyridine-2,6-diamine

There total 1 articles about (S)-3-aminomethyl-N₆-(5-cyclopropyl-1H-pyrazol-3-yl)-5-fluoro-N₂-[1-(4-fluorophenyl)ethyl]pyridine-2,6-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

(S)-6-(5-cyclopropyl-1H-pyrazol-3-ylamino)-5-fluoro-2-(1-(4-fluorophenyl)ethylamino)nicotinonitrile (905585-61-7,907218-68-2) → (S)-3-aminomethyl-N6-(5-cyclopropyl-1H-pyrazol-3-yl)-5-fluoro-N2-[1-(4-fluorophenyl)ethyl]pyridine-2,6-diamine (905585-65-1)

Guidance literature:

(S)-6-(5-cyclopropyl-1H-pyrazol-3-ylamino)-5-fluoro-2-(1-(4-fluorophenyl)ethylamino)nicotinonitrile; With hydrogenchloride; hydrogen; palladium 10% on activated carbon; In methanol; water; for 6h; under 2068.65 Torr;

With sodium carbonate; In methanol; dichloromethane; water;

Reference yield: 53.0%

(S)-3-aminomethyl-N6-(5-cyclopropyl-1H-pyrazol-3-yl)-5-fluoro-N2-[1-(4-fluorophenyl)ethyl]pyridine-2,6-diamine (905585-65-1) → (S)-N-((6-(5-cyclopropyl-1H-pyrazol-3-ylamino)-5-fluoro-2-(1-(4-fluorophenyl)-ethylamino)pyridin-3-yl)methyl)methanesulfonamide

Guidance literature:

With N-ethyl-N,N-diisopropylamine; dmap; In tetrahydrofuran; at 60 ℃; for 8h;

Reference yield: 51.0%

(S)-3-aminomethyl-N6-(5-cyclopropyl-1H-pyrazol-3-yl)-5-fluoro-N2-[1-(4-fluorophenyl)ethyl]pyridine-2,6-diamine (905585-65-1) + L-Pyroglutamic acid (98-79-3) → (S)-N-((6-(5-cyclopropyl-1H-pyrazol-3-ylamino)-5-fluoro-2-((S)-1-(4-fluorophenyl)ethylamino)pyridin-3-yl)methyl)-5-oxo-pyrrolidine-2-carboxamide (905586-72-3)

Guidance literature:

(S)-3-aminomethyl-N₆-(5-cyclopropyl-1H-pyrazol-3-yl)-5-fluoro-N₂-[1-(4-fluorophenyl)ethyl]pyridine-2,6-diamine; L-Pyroglutamic acid; With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; at 0 - 20 ℃; for 1h;

With water; sodium hydrogencarbonate; In tetrahydrofuran; dichloromethane;

upstream raw materials:

(S)-6-(5-cyclopropyl-1H-pyrazol-3-ylamino)-5-fluoro-2-(1-(4-fluorophenyl)ethylamino)nicotinonitrile

Downstream raw materials:

(R)-N-((6-(5-cyclopropyl-1H-pyrazol-3-ylamino)-5-fluoro-2-((S)-1-(4-fluorophenyl)ethylamino)pyridin-3-yl)methyl)-5-oxo-pyrrolidine-2-carboxamide

(S)-N-((6-(5-cyclopropyl-1H-pyrazol-3-ylamino)-5-fluoro-2-((S)-1-(4-fluorophenyl)ethylamino)pyridin-3-yl)methyl)-5-oxo-pyrrolidine-2-carboxamide

tert-butyl (2-{[(6-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-5-fluoro-2-{[(1S)-1-(4-fluorophenyl)ethyl]amino}pyridin-3-yl)methyl]amino}-2-oxoethyl)carbamate

N-((6-(5-cyclopropyl-1H-pyrazol-3-ylamino)-5-fluoro-2-((S)-1-(4-fluorophenyl)ethylamino)pyridin-3-yl)methyl)-5-oxo-pyrrolidine-2-carboxamide

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