4-(6-{2-[3-methoxy-4-(1,4,7,10-tetraoxa-13-aza-cyclopentadec-13-yl)-phenyl]-ethylamino}-1,3-dioxo-1H,3H-benzo[de]isoquinolin-2-ylmethyl)-benzoic acid tert-butyl ester

Base Information

Chemical Name:4-(6-{2-[3-methoxy-4-(1,4,7,10-tetraoxa-13-aza-cyclopentadec-13-yl)-phenyl]-ethylamino}-1,3-dioxo-1H,3H-benzo[de]isoquinolin-2-ylmethyl)-benzoic acid tert-butyl ester
CAS No.:497145-46-7
Molecular Formula:C₄₃H₅₁N₃O₉
Molecular Weight:753.893
Hs Code.:

4-(6-{2-[3-methoxy-4-(1,4,7,10-tetraoxa-13-aza-cyclopentadec-13-yl)-phenyl]-ethylamino}-1,3-dioxo-1<i>H</i>,3<i>H</i>-benzo[<i>de</i>]isoquinolin-2-ylmethyl)-benzoic acid <i>tert</i>-butyl ester

Synonyms:4-(6-{2-[3-methoxy-4-(1,4,7,10-tetraoxa-13-aza-cyclopentadec-13-yl)-phenyl]-ethylamino}-1,3-dioxo-1H,3H-benzo[de]isoquinolin-2-ylmethyl)-benzoic acid tert-butyl ester

Suppliers and Price of 4-(6-{2-[3-methoxy-4-(1,4,7,10-tetraoxa-13-aza-cyclopentadec-13-yl)-phenyl]-ethylamino}-1,3-dioxo-1H,3H-benzo[de]isoquinolin-2-ylmethyl)-benzoic acid tert-butyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4-(6-{2-[3-methoxy-4-(1,4,7,10-tetraoxa-13-aza-cyclopentadec-13-yl)-phenyl]-ethylamino}-1,3-dioxo-1H,3H-benzo[de]isoquinolin-2-ylmethyl)-benzoic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4-(6-{2-[3-methoxy-4-(1,4,7,10-tetraoxa-13-aza-cyclopentadec-13-yl)-phenyl]-ethylamino}-1,3-dioxo-1H,3H-benzo[de]isoquinolin-2-ylmethyl)-benzoic acid tert-butyl ester

There total 17 articles about 4-(6-{2-[3-methoxy-4-(1,4,7,10-tetraoxa-13-aza-cyclopentadec-13-yl)-phenyl]-ethylamino}-1,3-dioxo-1H,3H-benzo[de]isoquinolin-2-ylmethyl)-benzoic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 497145-43-4
2-[3-methoxy-4-(1,4,7,10-tetraoxa-13-aza-cyclopentadec-13-yl)-phenyl]-ethylamine

: 261789-05-3
4-chloro-1,8-naphthalic anhydride tert-butyl methyl benzoate

: 497145-46-7
4-(6-{2-[3-methoxy-4-(1,4,7,10-tetraoxa-13-aza-cyclopentadec-13-yl)-phenyl]-ethylamino}-1,3-dioxo-1H,3H-benzo[de]isoquinolin-2-ylmethyl)-benzoic acid tert-butyl ester

Guidance literature:: With 1-methyl-pyrrolidin-2-one; N-ethyl-N,N-diisopropylamine; at 100 ℃; for 15h;
DOI:10.1021/ac0205107

Reference yield:

: 19249-03-7
triethylene glycol di-(p-toluenesulfonate)

: 497145-46-7
4-(6-{2-[3-methoxy-4-(1,4,7,10-tetraoxa-13-aza-cyclopentadec-13-yl)-phenyl]-ethylamino}-1,3-dioxo-1H,3H-benzo[de]isoquinolin-2-ylmethyl)-benzoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 15 h / Reflux; Inert atmosphere

2.1: trichlorophosphate / 17 h / 60 °C

3.1: ammonium acetate; acetic acid / 0.17 h / 20 °C

3.2: 5 h / 60 °C

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 6 h

5.1: N-ethyl-N,N-diisopropylamine / 1-methyl-pyrrolidin-2-one / 15 h / 100 °C

With lithium aluminium tetrahydride; ammonium acetate; sodium hydride; acetic acid; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; mineral oil;

Reference yield:

: 98269-22-8
13-(2-methoxyphenyl)-1,4,7,10-tetraoxa-13-cyclopentadecane

: 497145-46-7
4-(6-{2-[3-methoxy-4-(1,4,7,10-tetraoxa-13-aza-cyclopentadec-13-yl)-phenyl]-ethylamino}-1,3-dioxo-1H,3H-benzo[de]isoquinolin-2-ylmethyl)-benzoic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 51 percent / POCl₃ / 17 h / 20 - 60 °C

2: 60 percent / NH₄OAc; AcOH / 5 h / 60 °C

3: LiAlH₄ / tetrahydrofuran / 4 h / Heating

4: 62 percent / diisopropylethylamine; N-methylpyrrolidinone / 15 h / 100 °C

With 1-methyl-pyrrolidin-2-one; lithium aluminium tetrahydride; ammonium acetate; acetic acid; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In tetrahydrofuran;
DOI:10.1021/ac0205107